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Literature summary for 7.6.2.3 extracted from

  • Ballatori, N.; Krance, S.; Marchan, R.; Hammond, C.
    Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology (2009), Mol. Aspects Med., 30, 13-28 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.6.2.3

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + glutathione disulfide[side 1] Homo sapiens
-
 ADP + phosphate + glutathione disulfide[side 2]
-
 ?
ATP + H2O + glutathione-S-conjugate[side 1] Homo sapiens
-
 ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
ATP + H2O + S-nitrosoglutathione[side 1] Homo sapiens
-
 ADP + phosphate + S-nitrosoglutathione[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens O95255
-
-
Homo sapiens P33527
-
-
Homo sapiens Q15439
-
-
Homo sapiens Q15440
-
-
Homo sapiens Q92887
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Homo sapiens
-
bladder
-
 Homo sapiens
-
brain
-
 Homo sapiens
-
breast
-
 Homo sapiens
-
colon
-
 Homo sapiens
-
gallbladder
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
ovary
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
prostate
-
 Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-
skin
-
 Homo sapiens
-
small intestine
-
 Homo sapiens
-
spleen
-
 Homo sapiens
-
stomach
-
 Homo sapiens
-
sweat gland
-
 Homo sapiens
-
testis
-
 Homo sapiens
-
thymus
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + glutathione disulfide[side 1]
-
 Homo sapiens ADP + phosphate + glutathione disulfide[side 2]
-
 ?
ATP + H2O + glutathione-S-conjugate[side 1]
-
 Homo sapiens ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
ATP + H2O + S-nitrosoglutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-nitrosoglutathione[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
ABCC1
-
 Homo sapiens
ABCC2
-
 Homo sapiens
ABCC4
-
 Homo sapiens
Abcc5
-
 Homo sapiens
Mpr6
-
 Homo sapiens
Mpr7
-
 Homo sapiens
Mpr8
-
 Homo sapiens
MRP1
-
 Homo sapiens
MRP2
-
 Homo sapiens
MRP4
-
 Homo sapiens
MRP5
-
 Homo sapiens
multidrug resistance-associated protein
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme plays an important role in cellular glutathione homeostasis and is implicated in apoptotic glutathione export. Because the Mrp proteins also mediate export of GSSG and glutathione S-conjugates and complexes, they likely contribute to the control of cellular redox status, delivery of cysteine to other tissues, export of signaling molecules, elimination of xenobiotics and reactive metabolic intermediates, as well as to cell differentiation, proliferation, and apoptosis Homo sapiens