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Literature summary for 7.6.2.3 extracted from

  • Keppler, D.; Leier, I.; Jedlitschky, G.
    Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2 (1997), Biol. Chem., 378, 787-791 .
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
canalicular membrane
-
Homo sapiens
-
-
plasma membrane
-
Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + glutathione-S-conjugate[side 1] Homo sapiens
-
ADP + phosphate + glutathione-S-conjugate[side 2]
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92887
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-
hepatocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + glutathione disulfide[side 1]
-
Homo sapiens ADP + phosphate + glutathione disulfide[side 2]
-
?
ATP + H2O + glutathione-S-conjugate[side 1]
-
Homo sapiens ADP + phosphate + glutathione-S-conjugate[side 2]
-
?
ATP + H2O + S-(17beta-glucuronosyl estradiol)glutathione[side 1]
-
Homo sapiens ADP + phosphate + S-(17beta-glucuronosyl estradiol)glutathione[side 2]
-
?
ATP + H2O + S-(6alpha-glucuronosyl hyodeoxycholate)glutathione[side 1]
-
Homo sapiens ADP + phosphate + S-(6alpha-glucuronosyl hyodeoxycholate)glutathione[side 2]
-
?
ATP + H2O + S-(bilirubin glucuronide)glutathione[side 1]
-
Homo sapiens ADP + phosphate + S-(bilirubin glucuronide)glutathione[side 2]
-
?
ATP + H2O + S-(C4-glutathione)glutathione[side 1]
-
Homo sapiens ADP + phosphate + S-(C4-glutathione)glutathione[side 2]
-
?

Synonyms

Synonyms Comment Organism
canalicular MRP
-
Homo sapiens
canalicular multispecific organic anion transporter
-
Homo sapiens
cMOAT
-
Homo sapiens
cMRP
-
Homo sapiens
MRP1
-
Homo sapiens
MRP2
-
Homo sapiens
multidrug resistance-associated protein 1
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is associated with multiple drug resistance of malignant tumors because of their capacity to pump drug conjugates and drug complexes across the plasma membrane into the extracellular space Homo sapiens