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Literature summary for 7.6.2.2 extracted from

  • Golin, J.; Ambudkar, S.V.
    The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters (2015), Biochem. J., 467, 353-363.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
D1042N the mutant exhibits an rhodamine 6G efflux rate that is 10% as high as that of the wild type Saccharomyces cerevisiae
S1368A the mutant has wild type enzyme levels as well as wild type ATPase activity and transmembrane signaling Saccharomyces cerevisiae
S558Y the mutation leads to markedly increased hypersensitivity towards all transport substrates Saccharomyces cerevisiae
V656A the mutation leads to markedly increased hypersensitivity towards all transport substrates Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
beryllium fluoride
-
Saccharomyces cerevisiae
clotrimazole
-
Saccharomyces cerevisiae
vanadate
-
Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Saccharomyces cerevisiae 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + xenobiotic/in Saccharomyces cerevisiae
-
ADP + phosphate + xenobiotic/out
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + clotrimazole/in
-
Saccharomyces cerevisiae ADP + phosphate + clotrimazole/out
-
?
ATP + H2O + rhodamine 6G/in
-
Saccharomyces cerevisiae ADP + phosphate + rhodamine 6G/out
-
?
ATP + H2O + xenobiotic/in
-
Saccharomyces cerevisiae ADP + phosphate + xenobiotic/out
-
?
CTP + H2O + rhodamine 6G/in low CTPase activity Saccharomyces cerevisiae CDP + phosphate + rhodamine 6G/out
-
?
GTP + H2O + rhodamine 6G/in
-
Saccharomyces cerevisiae GDP + phosphate + rhodamine 6G/out
-
?
UTP + H2O + rhodamine 6G/in low UTPase activity Saccharomyces cerevisiae UDP + phosphate + rhodamine 6G/out
-
?

Synonyms

Synonyms Comment Organism
PDR5
-
Saccharomyces cerevisiae