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Literature summary for 7.6.2.2 extracted from

  • Loe, D.W.; Stewart, R.K.; Massey, T.E.; Deeley, R.G.; Cole, S.P.C.
    ATP-dependent transport of aflatoxin B1 and its glutathione conjugate by the product of the multidrug resistance protein (MRP) gene (1997), Mol. Pharmacol., 51, 1034-1041.
    View publication on PubMed
Search for more literature for 7.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
16alpha-17beta-estradiol 17-(beta-D-glucuronide) transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens
17-beta-estradiol 17-beta-(D-glucuronide) transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens
17beta-estradiol 16-(beta-D-glucuronide) transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens
17beta-estradiol 3-sulfato-17-(beta-D-glucuronide) transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens
GSSG transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens
leukotriene D4 transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens
monoclonal antibiodies
-
 Homo sapiens
S-butyl glutathione transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens
S-decyl-glutathione
-
 Homo sapiens
S-hexyl glutathione transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens
S-octyl glutathione transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000189
-
 aflatoxin B1-epoxide-GSH conjugate/in
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens potential protective role for the enzyme in chemical carcinogenesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
H69 cell
-
 Homo sapiens
-
HEK-293 cell
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aflatoxin B1-epoxide-GSH conjugate/in + ATP + H2O
-
 Homo sapiens aflatoxin B1-epoxide-GSH conjugate/out + ADP + phosphate
-
 ?
aflatoxin B1/in + ATP + H2O
-
 Homo sapiens aflatoxin B1/out + ADP + phosphate
-
 ?
additional information potential protective role for the enzyme in chemical carcinogenesis Homo sapiens ?
-
 ?