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Literature summary for 7.6.2.1 extracted from
- C-terminus of the P4-ATPase ATP8A2 functions in protein folding and regulation of phospholipid flippase activity (2017), Mol. Biol. Cell, 28, 452-462 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | neither phosphatidylinositol nor phosphatidylinositol 4-phosphate have any significant effect on the phosphatidylserine-stimulated ATPase activity of the enzyme | Bos taurus | |
| phosphatidylserine | - |
Bos taurus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in PC-12 cells and HEK-293T cells | Bos taurus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S1138A | the mutant shows reduced activity compared to the wild type enzyme | Bos taurus |
| S1138D | the mutant shows slightly reduced activity compared to the wild type enzyme | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| Golgi apparatus | - |
Bos taurus | 5794 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + phosphatidylserine[side 1] | Bos taurus | - |
ADP + phosphate + phosphatidylserine[side 2] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | the enzyme undergoes phosphorylation on the serine residue within a CaMKII target motif | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + phosphatidylserine[side 1] | - |
Bos taurus | ADP + phosphate + phosphatidylserine[side 2] | - |
? | |
| additional information | no transport activity with phosphatidylinositol | Bos taurus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 120000, SDS-PAGE | Bos taurus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Atp8a2 | - |
Bos taurus |
| P4-ATPase | - |
Bos taurus |
| phosphatidylserine flippase | - |
Bos taurus |
| phospholipid flippase | - |
Bos taurus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 2.75 | - |
at pH and °C | Bos taurus | Ca2+ | |
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Release 2023.1 (January 2023)
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