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Literature summary for 7.6.2.1 extracted from

  • Tanaka, Y.; Ono, N.; Shima, T.; Tanaka, G.; Katoh, Y.; Nakayama, K.; Takatsu, H.; Shin, H.W.
    The phospholipid flippase ATP9A is required for the recycling pathway from the endosomes to the plasma membrane (2016), Mol. Biol. Cell, 27, 3883-3893 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.6.2.1

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
 Homo sapiens 5768
-
Golgi apparatus
-
 Homo sapiens 5794
-
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + phosphatidylserine[side 1] Homo sapiens
-
 ADP + phosphate + phosphatidylserine[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O75110
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + phosphatidylserine[side 1]
-
 Homo sapiens ADP + phosphate + phosphatidylserine[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
ATP9A
-
 Homo sapiens
P4-ATPase
-
 Homo sapiens
phospholipid flippase
-
 Homo sapiens
type IV P-type ATPase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme depletion delays the recycling of transferrin from endosomes to the plasma membrane and causes accumulation of glucose transporter 1 in endosomes, probably by inhibiting their recycling Homo sapiens
metabolism the enzyme is required for the recycling pathway from the endosomes to the plasma membrane Homo sapiens