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Literature summary for 7.6.2.1 extracted from

  • Naito, T.; Takatsu, H.; Miyano, R.; Takada, N.; Nakayama, K.; Shin, H.W.
    Phospholipid flippase ATP10A translocates phosphatidylcholine and is involved in plasma membrane dynamics (2015), J. Biol. Chem., 290, 15004-15017.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.6.2.1

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome localization requires an interaction with cell cycle control protein CDC50A Homo sapiens 5768
-
plasma membrane localization requires an interaction with cell cycle control protein CDC50A Homo sapiens 5886
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plasma membrane localization requires an interaction with cell cycle control protein CDC50A. Depletion of CDC50A causes isoform ATP10A to be retained at the endoplasmic reticulum and abrogates the increased phosphatidylcholine flipping activity observed by expression of ATP10A Homo sapiens 5886
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O60312
-
-
Homo sapiens O94823
-
-
Homo sapiens Q9P241
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + phosphatidylcholine/in
-
 Homo sapiens ADP + phosphate + phosphatidylcholine/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP10A
-
 Homo sapiens
ATP10B
-
 Homo sapiens
ATP10D
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function exogenous expression of isoform ATP10A dramatically increases phosphatidylcholine flipping but not flipping of phosphatidylserine or phosphatidylethanolamine Homo sapiens