Literature summary for 7.6.2.1 extracted from

Kato, U.; Inadome, H.; Yamamoto, M.; Emoto, K.; Kobayashi, T.; Umeda, M.
Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration (2013), J. Biol. Chem., 288, 4922-4934.

Search for more literature for 7.6.2.1

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	cell cycle control protein CDC50A associates with and recruits P4-ATPase ATP8A1 to the plasma membrane	Cricetulus griseus	5886	-

Organism

Organism	UniProt	Comment	Textmining
Cricetulus griseus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + phosphatidylethanolamine/in	-	Cricetulus griseus	ADP + phosphate + phosphatidylethanolamine/out	-	?

Synonyms

Synonyms	Comment	Organism
ATP8A1	-	Cricetulus griseus

General Information

General Information	Comment	Organism
physiological function	cell cycle control protein CDC50A associates with and recruites P4-ATPase ATP8A1 to the plasma membrane. Overexpression of CDC50A induces extensive cell spreading and greatly enhances cell migration. Depletion of either CDC50A or ATP8A1 causes a severe defect in the formation of membrane ruffles, thereby inhibiting cell migration. Depletion of CDC50A inhibits the inward translocation of both phosphatidylserine and phosphatidylethanolamine, whereas the depletion of ATP8A1 inhibits the translocation of phosphatidylethanolamine but not that of phosphatidylserine	Cricetulus griseus

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Release 2023.1 (January 2023)