Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NTI2 | - |
- |
Homo sapiens | Q9Y2Q0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ATP8A1 | - |
Homo sapiens |
Atp8a2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | depletion of isoform ATP8A1 impairs the asymmetric transbilayer distribution of phosphatidylserine in recycling endosomes, dissociates membrane fission protein EHD1 from recycling endosomes, and generates aberrant endosomal tubules that appear resistant to fission. Expression of isoform ATP8A2 rescues the endosomal defects in ATP8A1-depleted cells | Homo sapiens |
physiological function | depletion of isoform ATP8A1 impairs the asymmetric transbilayer distribution of phosphatidylserine in recycling endosomes, dissociates membrane fission protein EHD1 from recycling endosomes, and generates aberrant endosomal tubules that appear resistant to fission. Phosphatidylserine flipping by an recycling endosome-localized P4-ATPase is required for the recruitment of the membrane fission protein EHD1 | Homo sapiens |