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Literature summary for 7.6.2.1 extracted from

  • Nilsson, L.; Jonsson, E.; Tuck, S.
    Caenorhabditis elegans numb inhibits endocytic recycling by binding TAT-1 aminophospholipid translocase (2011), Traffic, 12, 1839-1849.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene tat-1, expression in Saccharomyces cerevisiae. Ability of NUM-1A to inhibit transport of phosphatidylserine is suppressed by multiple copies of tat-1C Caenorhabditis elegans

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
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Caenorhabditis elegans 5886
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Caenorhabditis elegans Tat-1 binds specifically NUM-1A, which regulates endocytic recycling in Caenorhabditis elegans ?
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?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans C7U324 gene tat-1C
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine TAT-1 is differentially spliced during development, isozyme TAT-1C-specific splicing occurs in the intestine Caenorhabditis elegans
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Tat-1 binds specifically NUM-1A, which regulates endocytic recycling in Caenorhabditis elegans Caenorhabditis elegans ?
-
?

Synonyms

Synonyms Comment Organism
TAT-1
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Caenorhabditis elegans
transbilayer amphipath transporter-1
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Caenorhabditis elegans

Cofactor

Cofactor Comment Organism Structure
ATP localization of the ATPase catalytic site Caenorhabditis elegans

General Information

General Information Comment Organism
malfunction inability of tat-1 mutants to take up 1-oleoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphoserine Caenorhabditis elegans
additional information Tat-1 binds specifically NUM-1A, which regulates endocytic recycling in Caenorhabditis elegans and modulates intestinal transport of phosphatidylserine Caenorhabditis elegans
physiological function transbilayer amphipath transporter-1, TAT-1 is a P4 family adenosine triphosphatase and putative aminophospholipid translocase that is required for proper endocytic trafficking. In the intestine, TAT-1 does not solely prevent the movement of phosphatidylserine from the cytosolic to the exoplasmic surface of cells but can promote its active transport across the plasma membrane into cells Caenorhabditis elegans