Cloned (Comment) | Organism |
---|---|
gene tat-1, expression in Saccharomyces cerevisiae. Ability of NUM-1A to inhibit transport of phosphatidylserine is suppressed by multiple copies of tat-1C | Caenorhabditis elegans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Caenorhabditis elegans | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Caenorhabditis elegans | Tat-1 binds specifically NUM-1A, which regulates endocytic recycling in Caenorhabditis elegans | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | C7U324 | gene tat-1C | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | TAT-1 is differentially spliced during development, isozyme TAT-1C-specific splicing occurs in the intestine | Caenorhabditis elegans | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Tat-1 binds specifically NUM-1A, which regulates endocytic recycling in Caenorhabditis elegans | Caenorhabditis elegans | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TAT-1 | - |
Caenorhabditis elegans |
transbilayer amphipath transporter-1 | - |
Caenorhabditis elegans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | localization of the ATPase catalytic site | Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
malfunction | inability of tat-1 mutants to take up 1-oleoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphoserine | Caenorhabditis elegans |
additional information | Tat-1 binds specifically NUM-1A, which regulates endocytic recycling in Caenorhabditis elegans and modulates intestinal transport of phosphatidylserine | Caenorhabditis elegans |
physiological function | transbilayer amphipath transporter-1, TAT-1 is a P4 family adenosine triphosphatase and putative aminophospholipid translocase that is required for proper endocytic trafficking. In the intestine, TAT-1 does not solely prevent the movement of phosphatidylserine from the cytosolic to the exoplasmic surface of cells but can promote its active transport across the plasma membrane into cells | Caenorhabditis elegans |