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Literature summary for 7.6.2.1 extracted from

  • Takatsu, H.; Baba, K.; Shima, T.; Umino, H.; Kato, U.; Umeda, M.; Nakayama, K.; Shin, H.W.
    ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner (2011), J. Biol. Chem., 286, 38159-38167.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.6.2.1

Cloned(Commentary)

Cloned (Comment) Organism
transient expression of of different combinations of C-terminally HA-tagged P4-ATPase ATP9A or ATP9B and an N-terminally FLAG-tagged CDC50 construct in HeLa cells, overview. Neither ATP9A nor ATP9B forms a stable complex with CDC50 proteins in the cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of a chimeric ATP9 protein by replacement of the N-terminal cytoplasmic region of ATP9A with the corresponding region of ATP9B, the mutant chimera is localized exclusively to the Golgi apparatus. The mutant ATP9B(53-126) construct retains the ability to localize to the Golgi Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum ATP9B is able to exit the endoplasmic reticulum in the absence of exogenous CDC50 expression Homo sapiens 5783
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endosome ATP9A localizes to endosomes and the trans-Golgi network Homo sapiens 5768
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Golgi apparatus ATP9B localizes to the trans-Golgi network in a CDC50 protein-independent manner Homo sapiens 5794
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membrane endomembrane localization of class 2 and 6 P4-ATPases, overview. ATP9A is localized to the early/recycling endosomes but not late endosomes and to the trans-Golgi network rather than the cis-Golgi. Unlike ATP9A, ATP9B is localized exclusively to the perinuclear region but not on EEA1-positive early endosomes Homo sapiens 16020
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trans-Golgi network ATP9A localizes to endosomes and the trans-Golgi network, whereas ATP9B localizes exclusively to the trans-Golgi network. The N-terminal cytoplasmic region ofATP9B is required for its Golgi localization Homo sapiens 5802
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
ATP10A
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 Homo sapiens
ATP10B
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 Homo sapiens
ATP10D
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 Homo sapiens
ATP11A
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 Homo sapiens
ATP11B
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 Homo sapiens
ATP11C
-
 Homo sapiens
ATP9A
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 Homo sapiens
ATP9B
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 Homo sapiens
P4-ATPase type IV P-type ATPase Homo sapiens
phospholipid flippase
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 Homo sapiens

General Information

General Information Comment Organism
evolution type IV P-type ATPases, P4-ATPases, are putative phospholipid flippases that translocate phospholipids from the exoplasmic (lumenal) to the cytoplasmic leaflet of lipid bilayers and function in complex with CDC50 proteins. Class 5, ATP10A, ATP10B, and ATP10D, and class 6, ATP11A, ATP11B, and ATP11C, P4-ATPases require CDC50 proteins, primarily CDC50A, for their exit from the endoplasmic reticulum and final subcellular localization. In contrast, class 2 P4-ATPases, ATP9A and ATP9B, are able to exit the endoplasmic reticulum in the absence of exogenous CDC50 expression: ATP9B, but not ATP11B, was able to exit the ER despite depletion of CDC50 proteins Homo sapiens
additional information ATP9B, a P4-ATPase and a putative aminophospholipid translocase, localizes to the trans-Golgi network in a CDC50 protein-independent manner. Neither ATP9A nor ATP9B forms a stable complex with CDC50 proteins in the cell Homo sapiens
physiological function the enzyme translocates phospholipids from the exoplasmic (lumenal) to the cytoplasmic leaflet of lipid bilayers Homo sapiens
physiological function type IV P-type ATPases, P4-ATPases, are putative phospholipid flippases that translocate phospholipids from the exoplasmic (lumenal) to the cytoplasmic leaflet of lipid bilayers and are believed to function in complex with CDC50 proteins Homo sapiens