Any feedback?
Literature summary for 7.6.2.1 extracted from
- Phospholipid flippases: Building asymmetric membranes and transport vesicles (2012), Biochim. Biophys. Acta, 1821, 1068-1077.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ALIS protein | - |
Arabidopsis thaliana | |
| CDC50A | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endosome | - |
Homo sapiens | 5768 | - |
| endosome | - |
Saccharomyces cerevisiae | 5768 | - |
| endosome | - |
Arabidopsis thaliana | 5768 | - |
| endosome | - |
Caenorhabditis elegans | 5768 | - |
| Golgi apparatus | - |
Homo sapiens | 5794 | - |
| Golgi apparatus | - |
Saccharomyces cerevisiae | 5794 | - |
| Golgi apparatus | - |
Arabidopsis thaliana | 5794 | - |
| Golgi apparatus | - |
Caenorhabditis elegans | 5794 | - |
| plasma membrane | - |
Homo sapiens | 5886 | - |
| plasma membrane | - |
Saccharomyces cerevisiae | 5886 | - |
| plasma membrane | - |
Arabidopsis thaliana | 5886 | - |
| plasma membrane | - |
Caenorhabditis elegans | 5886 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
| Caenorhabditis elegans | C7U324 | - |
- |
| Caenorhabditis elegans | G5EBH1 | - |
- |
| Caenorhabditis elegans | O18182 | - |
- |
| Caenorhabditis elegans | P91203 | - |
- |
| Caenorhabditis elegans | Q7YXV5 | - |
- |
| Homo sapiens | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Saccharomyces cerevisiae | P32660 | - |
- |
| Saccharomyces cerevisiae | P39524 | - |
- |
| Saccharomyces cerevisiae | Q12674 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | - |
Homo sapiens | - |
| erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + phosphatidylethanolamine/in | - |
Homo sapiens | ADP + phosphate + phosphatidylethanolamine/out | - |
? |  |
| ATP + H2O + phosphatidylethanolamine/in | - |
Saccharomyces cerevisiae | ADP + phosphate + phosphatidylethanolamine/out | - |
? | |
| ATP + H2O + phosphatidylethanolamine/in | - |
Arabidopsis thaliana | ADP + phosphate + phosphatidylethanolamine/out | - |
? | |
| ATP + H2O + phosphatidylethanolamine/in | - |
Caenorhabditis elegans | ADP + phosphate + phosphatidylethanolamine/out | - |
? | |
| ATP + H2O + phosphatidylserine/in | - |
Homo sapiens | ADP + phosphate + phosphatidylserine/out | - |
? | |
| ATP + H2O + phosphatidylserine/in | - |
Saccharomyces cerevisiae | ADP + phosphate + phosphatidylserine/out | - |
? | |
| ATP + H2O + phosphatidylserine/in | - |
Arabidopsis thaliana | ADP + phosphate + phosphatidylserine/out | - |
? | |
| ATP + H2O + phosphatidylserine/in | - |
Caenorhabditis elegans | ADP + phosphate + phosphatidylserine/out | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | - |
Homo sapiens |
| heterodimer | - |
Saccharomyces cerevisiae |
| heterodimer | - |
Arabidopsis thaliana |
| heterodimer | - |
Caenorhabditis elegans |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ALA1 | - |
Arabidopsis thaliana |
| ALA10 | - |
Arabidopsis thaliana |
| ALA11 | - |
Arabidopsis thaliana |
| ALA12 | - |
Arabidopsis thaliana |
| ALA2 | - |
Arabidopsis thaliana |
| ALA3 | - |
Arabidopsis thaliana |
| ALA4 | - |
Arabidopsis thaliana |
| ALA5 | - |
Arabidopsis thaliana |
| ALA7 | - |
Arabidopsis thaliana |
| ALA8 | - |
Arabidopsis thaliana |
| ALA9 | - |
Arabidopsis thaliana |
| aminophospholipid ATPase | - |
Arabidopsis thaliana |
| aminophospholipid translocase | - |
Homo sapiens |
| APLT | - |
Homo sapiens |
| ATP10A | - |
Homo sapiens |
| ATP10B | - |
Homo sapiens |
| ATP10D | - |
Homo sapiens |
| ATP11A | - |
Homo sapiens |
| ATP11B | - |
Homo sapiens |
| ATP11C | - |
Homo sapiens |
| ATP8A1 | - |
Homo sapiens |
| Atp8a2 | - |
Homo sapiens |
| ATP8B1 | - |
Homo sapiens |
| ATP8B2 | - |
Homo sapiens |
| ATP8B3 | - |
Homo sapiens |
| ATP8B4 | - |
Homo sapiens |
| ATP8B5 | - |
Homo sapiens |
| ATP9A | - |
Homo sapiens |
| ATP9B | - |
Homo sapiens |
| Dnf1 | | Drs2 Neo1 family ATPase 1 | Saccharomyces cerevisiae |
| Dnf2 | Drs2 Neo1 family ATPase 2 | Saccharomyces cerevisiae |
| Dnf3 | Drs2 Neo1 family ATPase 3 | Saccharomyces cerevisiae |
| Drs2 | defect in ribosome synthesis 2 | Saccharomyces cerevisiae |
| Neo1 | neomycin resistance 1 | Saccharomyces cerevisiae |
| P4-ATPase | - |
Homo sapiens |
| P4-ATPase | - |
Saccharomyces cerevisiae |
| P4-ATPase | - |
Arabidopsis thaliana |
| P4-ATPase | - |
Caenorhabditis elegans |
| phospholipid flippase | - |
Homo sapiens |
| phospholipid flippase | - |
Saccharomyces cerevisiae |
| phospholipid flippase | - |
Arabidopsis thaliana |
| phospholipid flippase | - |
Caenorhabditis elegans |
| TAT-2 | - |
Caenorhabditis elegans |
| TAT-3 | - |
Caenorhabditis elegans |
| TAT-4 | - |
Caenorhabditis elegans |
| TAT-5 | - |
Caenorhabditis elegans |
| TAT-6 | - |
Caenorhabditis elegans |
| transbilayer amphipath transporter | - |
Caenorhabditis elegans |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | knockdown of ALA1 expression causes a cold-sensitive growth defect in plants | Arabidopsis thaliana |
| malfunction | P4-ATPase deficiencies are linked to liver disease, obesity, diabetes, hearing loss, neurological deficits, immune deficiency, and reduced fertility | Homo sapiens |
| physiological function | the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes | Homo sapiens |
| physiological function | the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Fippase helps to form transport vesicles that bud from Golgi and endosomal membranes | Caenorhabditis elegans |
| physiological function | the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Flippase helps to form transport vesicles that bud from Golgi and endosomal membranes | Saccharomyces cerevisiae |
| physiological function | the enzyme flips phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. Flippase helps to form transport vesicles that bud from Golgi and endosomal membranes | Arabidopsis thaliana |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
