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Literature summary for 7.6.2.1 extracted from
- Effects of monoglycerides on P-glycoprotein: modulation of the activity and expression in Caco-2 cell monolayers (2008), Mol. Pharm., 5, 863-875.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-monoolein | 0.5 mM significantly reduce the P-glycoprotein protein expression, 0.1 mM of 1-monoolein does not have any significant effect on the expression of P-glycoprotein | Homo sapiens |  |
| 1-monostearin | 0.5 mM significantly reduce the P-glycoprotein protein expression, 0.1 mM of 1-monostearin does not have any significant effect on the expression of P-glycoprotein | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 170000 | - |
SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Caco-2 cell | - |
Homo sapiens | - |
| colonic adenocarcinoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | - |
Homo sapiens | ADP + phosphate | - |
? | |
| ATP + H2O + rhodamine 123/out | - |
Homo sapiens | ADP + phosphate + rhodamine 123/in | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| P-glycoprotein | - |
Homo sapiens |
| P-gp | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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