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Literature summary for 7.6.2.1 extracted from
- Roles for the Drs2p-Cdc50p complex in protein transport and phosphatidylserine asymmetry of the yeast plasma membrane (2006), Traffic, 7, 1503-1517.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene swa4, DNA and amino acid sequence determination and anaylsis, comparison to the allelic gene cdc50 | Saccharomyces cerevisiae |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | deletion mutants of drs2 and cdc50, DELTAdrs2 and DELTAcdc50, exhibit a clathrin-deficient phenotype with delayed transport of carboxypeptidase Y to the vacuole, mislocation of resident TGN enzymes and the accumulation of aberrant membrane structures, the mutations cause a loss in plasma membrane phosphatidylserine asymmetry leading to disruption of protein trafficking, phenotypes, overview | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| chromaffin granule | - |
Saccharomyces cerevisiae | 42583 | - |
| Golgi apparatus | trans Golgi network | Saccharomyces cerevisiae | 5794 | - |
| Golgi membrane | - |
Saccharomyces cerevisiae | 139 | - |
| plasma membrane | - |
Saccharomyces cerevisiae | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + phospholipid/in | Saccharomyces cerevisiae | the enzyme is involved in protein trafficking, Drs2p acts in complex with the allelic CDC50 protein in ATP-dependent phosphatidylserine translocation playing a role in restricting the substrate to the cytosolic leaflet of the Golgi and the plasma membrane, overview | ADP + phosphate + phospholipid/out | - |
? |  |
| ATP + H2O + phospholipid/in | Saccharomyces cerevisiae CCY 2811 | the enzyme is involved in protein trafficking, Drs2p acts in complex with the allelic CDC50 protein in ATP-dependent phosphatidylserine translocation playing a role in restricting the substrate to the cytosolic leaflet of the Golgi and the plasma membrane, overview | ADP + phosphate + phospholipid/out | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
gene swa4 | - |
| Saccharomyces cerevisiae CCY 2811 | - |
gene swa4 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme from chromaffin granules | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + phospholipid/in | - |
Saccharomyces cerevisiae | ADP + phosphate + phospholipid/out | - |
? | |
| ATP + H2O + phospholipid/in | the enzyme is involved in protein trafficking, Drs2p acts in complex with the allelic CDC50 protein in ATP-dependent phosphatidylserine translocation playing a role in restricting the substrate to the cytosolic leaflet of the Golgi and the plasma membrane, overview | Saccharomyces cerevisiae | ADP + phosphate + phospholipid/out | - |
? | |
| ATP + H2O + phospholipid/in | - |
Saccharomyces cerevisiae CCY 2811 | ADP + phosphate + phospholipid/out | - |
? | |
| ATP + H2O + phospholipid/in | the enzyme is involved in protein trafficking, Drs2p acts in complex with the allelic CDC50 protein in ATP-dependent phosphatidylserine translocation playing a role in restricting the substrate to the cytosolic leaflet of the Golgi and the plasma membrane, overview | Saccharomyces cerevisiae CCY 2811 | ADP + phosphate + phospholipid/out | - |
? | |
| additional information | complex formation of Drs2p with CDC50, overview | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | complex formation of Drs2p with CDC50, overview | Saccharomyces cerevisiae CCY 2811 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Drs2p | - |
Saccharomyces cerevisiae |
| More | the enzyme belongs to the P-type ATPases | Saccharomyces cerevisiae |
| phosphatidylserine flippase | - |
Saccharomyces cerevisiae |
| phosphatidylserine translocase | - |
Saccharomyces cerevisiae |
| PS flippase | - |
Saccharomyces cerevisiae |
| PS translocase | - |
Saccharomyces cerevisiae |
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