Activating Compound | Comment | Organism | Structure |
---|---|---|---|
WAH-1 | a mitochondrial apoptogenic factor, a homologue of the apoptosis-inducing factor, AIF, required for externalization of phosphatidylserine to the cell surface of apoptotic cells. The Wah-1 effect is specific and independent of age, phenotypes of siRNA mutants and overexpressing mutants, overview | Caenorhabditis elegans |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of two deletion null mutants of scrm-1, mutants tm698 and tm805, which show more cell corpse than the wild-type embryos and a defect in cell corps engulfment, the average cell corpse duration in mutant scrm-1 tm698 is 55 min, in mutant scrm-1 tm805 57 in, and in wild-type embryos 33 min. The mutants also show highly decreased externalization of phosphatidylserine on the surface of apoptotic germ cells, phenotypes, overview | Caenorhabditis elegans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Caenorhabditis elegans | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Caenorhabditis elegans | the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface of apoptotic germ cells, a conserved event in worms, after activation by WAH-1, a mitochondrially released apoptotic factor, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Caenorhabditis elegans | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface of apoptotic germ cells, a conserved event in worms, after activation by WAH-1, a mitochondrially released apoptotic factor, overview | Caenorhabditis elegans | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phospholipid scramblase | - |
Caenorhabditis elegans |
SCRM-1 | - |
Caenorhabditis elegans |