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Literature summary for 7.6.2.1 extracted from
- Endocytic recycling in yeast is regulated by putative phospholipid translocases and the Ypt31p/32p-Rcy1p pathway (2007), Mol. Biol. Cell, 18, 295-312.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| genes DRS2, DNF1 and DNF2, and DNF3, expression of wild-type and mutant enzymes, overview | Saccharomyces cerevisiae |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of deletion mutants of phosphilipid translocases and CDC50 proteins, phenotypes, detailed overview | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endosome | - |
Saccharomyces cerevisiae | 5768 | - |
| plasma membrane | - |
Saccharomyces cerevisiae | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + phospholipid/in | Saccharomyces cerevisiae | phospholipid translocases are involved in the generation of phospholipid asymmetry in membrane bilayers | ADP + phosphate + phospholipid/out | - |
? |  |
| additional information | Saccharomyces cerevisiae | endocytic recycling in yeast is regulated by putative phospholipid translocases and the Ypt31p/32p-Rcy1p pathway, overview. The homologous proteins Cdc50p, Lem3p, and Crf1p are potential noncatalytic subunits of Drs2p, Dnf1p and Dnf2p, and Dnf3p, respectively, these putative heteromeric PLTs share an essential function for cell growth, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
several strains, genes DRS2, DNF1 and DNF2, and DNF3 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + phospholipid/in | - |
Saccharomyces cerevisiae | ADP + phosphate + phospholipid/out | - |
? | |
| ATP + H2O + phospholipid/in | phospholipid translocases are involved in the generation of phospholipid asymmetry in membrane bilayers | Saccharomyces cerevisiae | ADP + phosphate + phospholipid/out | - |
? | |
| additional information | endocytic recycling in yeast is regulated by putative phospholipid translocases and the Ypt31p/32p-Rcy1p pathway, overview. The homologous proteins Cdc50p, Lem3p, and Crf1p are potential noncatalytic subunits of Drs2p, Dnf1p and Dnf2p, and Dnf3p, respectively, these putative heteromeric PLTs share an essential function for cell growth, overview | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | Cdc50 family proteins form complexes with Drs2 family proteins, overview | Saccharomyces cerevisiae | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | the homologous proteins Cdc50p, Lem3p, and Crf1p are potential noncatalytic subunits of Drs2p, Dnf1p and Dnf2p, and Dnf3p, respectively, Cdc50 family proteins form complexes with Drs2 family proteins, overview | Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Drs2p | - |
Saccharomyces cerevisiae |
| More | DRS2 belongs to the DRS2 gene family of type 4 P-type ATPases | Saccharomyces cerevisiae |
| phospholipid translocase | - |
Saccharomyces cerevisiae |
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