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Literature summary for 7.6.2.1 extracted from
- Prolonged storage of red blood cells affects aminophospholipid translocase activity (2006), Vox Sang., 91, 244-251.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | exposure of cells to singlet oxygen is required for activity in freshly isolated erythrocytes | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NEM | - |
Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Homo sapiens | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activates | Homo sapiens | |
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + phosphatidylserine/out | Homo sapiens | flippase activity: transport from the outer to the inner leaflet of the plasma membrane | ADP + phosphate + phosphatidylserine/in | - |
? | |
| phosphatidylcholine/out | Homo sapiens | - |
phosphatidylcholine/in | - |
? | |
| phosphatidylserine/in | Homo sapiens | - |
phosphatidylserine/out | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 35 days, stored erythrocytes show nearly no enzyme activity, but the activity can be restored, overview | Homo sapiens |
| 4°C, 35 days, stored erythrocytes show pH-dependently reduced flippase activity and ATP depletion, upon ATP supply the activity can be restored, overview | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + phosphatidylserine/out | flippase activity: transport from the outer to the inner leaflet of the plasma membrane | Homo sapiens | ADP + phosphate + phosphatidylserine/in | - |
? | |
| additional information | the enzyme depends on ATP | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is independent of ATP | Homo sapiens | ? | - |
? | |
| phosphatidylcholine/out | - |
Homo sapiens | phosphatidylcholine/in | - |
? | |
| phosphatidylserine/in | - |
Homo sapiens | phosphatidylserine/out | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aminophospholipid translocase | - |
Homo sapiens |
| flippase | - |
Homo sapiens |
| phospholipid scrambling activity | - |
Homo sapiens |
| scramblase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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