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Literature summary for 7.6.2.1 extracted from

  • Fuchs, M.; Carey, M.C.; Cohen, D.E.
    Evidence for an ATP-independent long-chain phosphatidylcholine translocator in hepatocyte membranes (1997), Am. J. Physiol. Gastrointest. Liver Physiol., 273, 1312-1319.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information no effect by ATP Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by verapamil, no effect by ATP Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-
plasma membrane canalicular and basolateral Rattus norvegicus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + phospholipid/out Rattus norvegicus the enzyme is essential for ATP-independent externalization of long-chain phospholipids from hepatocytes and secretion to the bile across the canalicular plasma membrane ADP + phosphate + phospholipid/in
-
?

Organism

Organism UniProt Comment Textmining
no activity in Xenopus laevis
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + phospholipid/out
-
Rattus norvegicus ADP + phosphate + phospholipid/in
-
?
ATP + phospholipid/out the enzyme is essential for ATP-independent externalization of long-chain phospholipids from hepatocytes and secretion to the bile across the canalicular plasma membrane Rattus norvegicus ADP + phosphate + phospholipid/in
-
?
long-chain phospholipid/out
-
Rattus norvegicus long-chain phospholipid/in
-
?
phosphatidylcholine/out L-alpha-1-palmitoyl-2-linoleoyl-labeled substrate Rattus norvegicus phosphatidylcholine/in
-
?
phosphatidylethanolamine/out
-
Rattus norvegicus phosphatidylethanolamine/in
-
?

Synonyms

Synonyms Comment Organism
ATP-independent flippase
-
no activity in Xenopus laevis
ATP-independent long-chain phosphatidylcholine translocator
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Rattus norvegicus