Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | no effect by ATP | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition by verapamil, no effect by ATP | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
plasma membrane | canalicular and basolateral | Rattus norvegicus | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + phospholipid/out | Rattus norvegicus | the enzyme is essential for ATP-independent externalization of long-chain phospholipids from hepatocytes and secretion to the bile across the canalicular plasma membrane | ADP + phosphate + phospholipid/in | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
no activity in Xenopus laevis | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + phospholipid/out | - |
Rattus norvegicus | ADP + phosphate + phospholipid/in | - |
? | |
ATP + phospholipid/out | the enzyme is essential for ATP-independent externalization of long-chain phospholipids from hepatocytes and secretion to the bile across the canalicular plasma membrane | Rattus norvegicus | ADP + phosphate + phospholipid/in | - |
? | |
long-chain phospholipid/out | - |
Rattus norvegicus | long-chain phospholipid/in | - |
? | |
phosphatidylcholine/out | L-alpha-1-palmitoyl-2-linoleoyl-labeled substrate | Rattus norvegicus | phosphatidylcholine/in | - |
? | |
phosphatidylethanolamine/out | - |
Rattus norvegicus | phosphatidylethanolamine/in | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATP-independent flippase | - |
no activity in Xenopus laevis |
ATP-independent long-chain phosphatidylcholine translocator | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Rattus norvegicus |