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Literature summary for 7.6.2.1 extracted from
- Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter (2001), Biochemistry, 40, 6937-6947.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cyclosporin A | inhibition of phospholipid flipping | Mesocricetus auratus |  |
| vanadate | 75% inhibition of ATP hydrolysis at 0.1 mM vanadate | Mesocricetus auratus | |
| verapamil | inhibition of phospholipid flipping | Mesocricetus auratus | |
| vinblastine | inhibition of phospholipid flipping | Mesocricetus auratus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mesocricetus auratus | the lipid flippase activity of enzyme is associated with its drug transport function | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mesocricetus auratus | - |
multidrug resistance chinese hamster | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| ovary cell line | - |
Mesocricetus auratus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | - |
Mesocricetus auratus | ADP + phosphate | - |
? | |
| additional information | the lipid flippase activity of enzyme is associated with its drug transport function | Mesocricetus auratus | ? | - |
? | |
| additional information | the enzyme translocates phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin | Mesocricetus auratus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| P-glycoprotein | - |
Mesocricetus auratus |
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Release 2023.1 (January 2023)
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