Literature summary for 7.6.2.1 extracted from

Ding, J.; Wu, Z.; Crider, B.P.; Ma, Y.; LI, X.; Slaughter, C.; Gong, L.; Xie, X.S.
Identification and functional expression of four isoforms of ATPase II, the putative aminophospholipid translocase (2000), J. Biol. Chem., 275, 23378-13386.

Search for more literature for 7.6.2.1

Cloned(Commentary)

Cloned (Comment)	Organism
-	Bos taurus

Inhibitors

Inhibitors	Comment	Organism	Structure
vanadate	-	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lipid particle	-	Bos taurus	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O	Bos taurus	the enzyme plays an important role in the maintenance of membrane phospholipid asymmetry, observed in plasma membrane and membranes of certain cellular organelles	ADP + phosphate	-	?
ATP + H2O	Bos taurus	phosphatidylserine is essential for the dephosphorylation of the phosphoenzyme intermediate. Without phosphatidylserine, ATPase II accumulates as phosphoenzyme in the presence of ATP, resulting in the interruption of its catalytic cycle	ADP + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	Q29449	4 isoforms of ATPase II	-

Purification (Commentary)

Purification (Comment)	Organism
-	Bos taurus

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2]	P-type ATPase	Bos taurus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O	phosphatidylserine is essential for the dephosphorylation of the phosphoenzyme intermediate	Bos taurus	ADP + phosphate	-	?
ATP + H2O	the enzyme plays an important role in the maintenance of membrane phospholipid asymmetry, observed in plasma membrane and membranes of certain cellular organelles	Bos taurus	ADP + phosphate	-	?
ATP + H2O	phosphatidylserine is essential for the dephosphorylation of the phosphoenzyme intermediate. Without phosphatidylserine, ATPase II accumulates as phosphoenzyme in the presence of ATP, resulting in the interruption of its catalytic cycle	Bos taurus	ADP + phosphate	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)