Inhibitors | Comment | Organism | Structure |
---|---|---|---|
elaiophylin | partial inhibition of Mg+-ATPase activity, translocation of phosphatidylserine is almost completely abolished | Homo sapiens | |
eosin Y | almost complete inhibition of both Mg2+-ATPase activity and translocation | Homo sapiens | |
suramin | competitive inhibitor of ATP towards both Mg2+-ATPase activity and aminophospholipid translocation. Inhibition of translocation occurs at higher inhibitor concentration than the inhibition of Mg2+-ATPase activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.211 | - |
ATP | phosphatase activity | Homo sapiens | |
0.225 | - |
ATP | phosphatidylserine translocase activity | Homo sapiens | |
1.03 | - |
acetyl phosphate | phosphatase activity | Homo sapiens | |
1.17 | - |
p-nitrophenyl phosphate | phosphatase activity, detection of p-nitrophenolate formation from trichloroacetic acid precipitates | Homo sapiens | |
1.31 | - |
acetyl phosphate | phosphatidylserine translocase activity | Homo sapiens | |
1.39 | - |
p-nitrophenyl phosphate | phosphatidylserine translocase activity | Homo sapiens | |
1.46 | - |
p-nitrophenyl phosphate | phosphatase activity, continous detection of p-nitrophenolate formation in ghost at neutral pH | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Homo sapiens | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2] | P-type ATPase | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl phosphate + H2O | translocation of phosphatidylserine from the outer to the inner leaflet of resealed erythrocyte ghosts | Homo sapiens | acetate + phosphate | - |
? | |
ATP + H2O | translocation of phosphatidylserine from the outer to the inner leaflet of resealed erythrocyte ghosts | Homo sapiens | ADP + phosphate | - |
? | |
p-nitrophenyl phosphate + H2O | translocation of phosphatidylserine from the outer to the inner leaflet of resealed erythrocyte ghosts | Homo sapiens | p-nitrophenol + phosphate | - |
? |