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Literature summary for 7.4.2.8 extracted from

  • Aguilera, L.; Ferreira, E.; Gimenez, R.; Fernandez, F.J.; Taules, M.; Aguilar, J.; Vega, M.C.; Badia, J.; Baldoma, L.
    Secretion of the housekeeping protein glyceraldehyde-3-phosphate dehydrogenase by the LEE-encoded type III secretion system in enteropathogenic Escherichia coli (2012), Int. J. Biochem. Cell Biol., 44, 955-962.
    View publication on PubMed
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Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Escherichia coli
-
 ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli B7UMA6 enteropathogenic, gene escN
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Escherichia coli ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
EscN
-
 Escherichia coli
type III ATPase
-
 Escherichia coli

General Information

General Information Comment Organism
malfunction secretion of glyceraldehyde-3-phosphate dehydrogenase is abolished in mutants defective in the type III ATPase EscN. Complementation with escN gene restores GAPDH secretion Escherichia coli
metabolism enteropathogenic (EPEC) Escherichia coli secrete GAPDH through a type III secretion system into the culture medium. GAPDH secretion is not linked to outer membrane vesicles and depends on growth conditions. The secretion process is often dependent on a bacterial chaperone. The chaperone CesT displays broad substrate specificity and plays a central role in the recruitment of multiple type III effectors to the T3SS apparatus Escherichia coli