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Literature summary for 7.4.2.8 extracted from

  • Gong, L.; Lai, S.C.; Treerat, P.; Prescott, M.; Adler, B.; Boyce, J.D.; Devenish, R.J.
    Burkholderia pseudomallei type III secretion system cluster 3 ATPase BsaS, a chemotherapeutic target for small-molecule ATPase inhibitors (2015), Infect. Immun., 83, 1276-1285.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.4.2.8

Application

Application Comment Organism
drug development the enzyme is a chemotherapeutic target for small-molecule ATPase inhibitors Burkholderia pseudomallei
pharmacology the enzyme is a chemotherapeutic target for small-molecule ATPase inhibitors Burkholderia pseudomallei

Protein Variants

Protein Variants Comment Organism
additional information generation of a bsaS deletion mutant, the bsaS deletion mutant is highly attenuated for virulence in BALB/c mice Burkholderia pseudomallei

Inhibitors

Inhibitors Comment Organism Structure
ATPase inhibitor compound 939
-
 Burkholderia pseudomallei

Organism

Organism UniProt Comment Textmining
Burkholderia pseudomallei Q63K25 gene bsaS
-
Burkholderia pseudomallei K96243 Q63K25 gene bsaS
-

Synonyms

Synonyms Comment Organism
BsaS
-
 Burkholderia pseudomallei
More cf. EC 3.6.3.14 Burkholderia pseudomallei
TTSS ATPase
-
 Burkholderia pseudomallei
type III secretion system cluster 3 ATPase
-
 Burkholderia pseudomallei

General Information

General Information Comment Organism
malfunction loss of enzyme BsaS function either via direct genetic inactivation or treatment with the inhibitor compound 939 results in increased susceptibility of Burkholderia pseudomallei to microtubule-associated protein light chain 3-associated phagocytosis in infected RAW 264.7 cells, leading to elevated levels of intracellular killing. The bsaS deletion mutant is highly attenuated for virulence in BALB/c mice Burkholderia pseudomallei