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Literature summary for 7.4.2.8 extracted from

  • Hueck, C.J.
    Type III protein secretion system in bacterial pathogens of animals and plants (1998), Microbiol. Mol. Biol. Rev., 62, 379-433.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.4.2.8

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 length of proteins in amino acids Salmonella enterica subsp. enterica serovar Typhimurium
additional information
-
 length of proteins in amino acids Pseudomonas aeruginosa
additional information
-
 length of proteins in amino acids Xanthomonas campestris
additional information
-
 length of proteins in amino acids Pseudomonas syringae
additional information
-
 length of proteins in amino acids Erwinia sp.
additional information
-
 length of proteins in amino acids Ralstonia solanacearum
additional information
-
 length of proteins in amino acids Chlamydia sp.
additional information
-
 length of proteins in amino acids Shigella flexneri

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Escherichia coli
-
 ADP + phosphate
-
 ?
ATP + H2O Xanthomonas campestris secretion of polygalacturonase ADP + phosphate
-
 ?
ATP + H2O Aeromonas hydrophila secretion of amylase and protease ADP + phosphate
-
 ?
ATP + H2O Erwinia sp. secretion of pectic enzymes and cellulase by the type II secretion system ADP + phosphate
-
 ?
ATP + H2O Pseudomonas aeruginosa secretion of elastase, exotoxin A, phospholipase C, and other proteins ADP + phosphate
-
 ?
ATP + H2O Salmonella enterica subsp. enterica serovar Typhimurium secreted proteins, their biochemical activity and interaction with host or other proteins, overview ADP + phosphate
-
 ?
ATP + H2O Pseudomonas aeruginosa secreted proteins, their biochemical activity and interaction with host or other proteins, overview ADP + phosphate
-
 ?
ATP + H2O Pseudomonas syringae secreted proteins, their biochemical activity and interaction with host or other proteins, overview ADP + phosphate
-
 ?
ATP + H2O Erwinia sp. secreted proteins, their biochemical activity and interaction with host or other proteins, overview ADP + phosphate
-
 ?
ATP + H2O Ralstonia solanacearum secreted proteins, their biochemical activity and interaction with host or other proteins, overview ADP + phosphate
-
 ?
ATP + H2O Yersinia sp. secreted proteins, their biochemical activity and interaction with host or other proteins, overview ADP + phosphate
-
 ?
ATP + H2O Shigella flexneri secreted proteins, their biochemical activity and interaction with host or other proteins, overview ADP + phosphate
-
 ?
ATP + H2O Yersinia sp. pathogens use the type III system as a key virulence mechanism ADP + phosphate
-
 ?
ATP + H2O Shigella flexneri pathogens use the type III system as a key virulence mechanism ADP + phosphate
-
 ?
ATP + H2O Pseudomonas aeruginosa type II secretion is the primary pathway for the secretion of extracellular degradative enzymes by gram-negative bacteria ADP + phosphate
-
 ?
ATP + H2O Aeromonas hydrophila type II secretion is the primary pathway for the secretion of extracellular degradative enzymes by gram-negative bacteria ADP + phosphate
-
 ?
ATP + H2O Xanthomonas campestris type II secretion is the primary pathway for the secretion of extracellular degradative enzymes by gram-negative bacteria ADP + phosphate
-
 ?
ATP + H2O Erwinia sp. type II secretion is the primary pathway for the secretion of extracellular degradative enzymes by gram-negative bacteria ADP + phosphate
-
 ?
ATP + H2O Salmonella enterica subsp. enterica serovar Typhimurium the two type II secretion systems, SPI-1 and SPI-2 appear to play different roles during pathogenesis, with SPI-1 being required for initial penetration of the intestinal mucosa and SPI-2 necessary for subsequent systemic stages of infection ADP + phosphate
-
 ?
ATP + H2O Yersinia sp. the type III secretion mechanism enables Yersinia sp. to inject a number of essential virulence determinants into the cytosol of host target cells. The injected proteins appear to interfere with host cell signal transduction pathway and other cellular processes, allowing Yersinia sp. to obstruct the primary immune response and to establish a systemic infaction ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Aeromonas hydrophila
-
-
-
Bordetella pertussis
-
 type IV secretion system
-
Chlamydia sp.
-
-
-
Erwinia sp.
-
 type III secretion system
-
Erwinia sp.
-
 type II secretion system
-
Escherichia coli
-
 enteropathogenic
-
Helicobacter pylori
-
 type IV secretion system
-
Klebsiella oxytoca
-
 type II secretion system
-
Pseudomonas aeruginosa
-
 type II protein secretion sytem
-
Pseudomonas syringae
-
-
-
Ralstonia solanacearum
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
 type III secretion system
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
 two type III secretion systems, which are encoded by two distinct gene clusters termed SPI-1 and SPI-2
-
Shigella flexneri
-
 type III secretion system
-
Xanthomonas campestris
-
 type II secretion apparatus
-
Yersinia enterolytica
-
-
-
Yersinia sp.
-
 type III secretion system
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Escherichia coli ADP + phosphate
-
 ?
ATP + H2O
-
 Klebsiella oxytoca ADP + phosphate
-
 ?
ATP + H2O
-
 Yersinia enterolytica ADP + phosphate
-
 ?
ATP + H2O
-
 Chlamydia sp. ADP + phosphate
-
 ?
ATP + H2O secretion of polygalacturonase Xanthomonas campestris ADP + phosphate
-
 ?
ATP + H2O secretion of amylase and protease Aeromonas hydrophila ADP + phosphate
-
 ?
ATP + H2O secretion of pectic enzymes and cellulase by the type II secretion system Erwinia sp. ADP + phosphate
-
 ?
ATP + H2O secretion of elastase, exotoxin A, phospholipase C, and other proteins Pseudomonas aeruginosa ADP + phosphate
-
 ?
ATP + H2O a signature of the sec-dependent protein transport, by the type II and the type IV secretion, is the presence of a short, about 30 amino acids, mainly hydrophobic amino-terminal signal sequence in the exported protein. The signal sequence aids protein export and is cleaved off by a periplasmic signal peptidase when the exported protein reaches the periplasm Pseudomonas aeruginosa ADP + phosphate
-
 ?
ATP + H2O a signature of the sec-dependent protein transport, by the type II and the type IV secretion, is the presence of a short, about 30 amino acids, mainly hydrophobic amino-terminal signal sequence in the exported protein. The signal sequence aids protein export and is cleaved off by a periplasmic signal peptidase when the exported protein reaches the periplasm Helicobacter pylori ADP + phosphate
-
 ?
ATP + H2O a signature of the sec-dependent protein transport, by the type II and the type IV secretion, is the presence of a short, about 30 amino acids, mainly hydrophobic amino-terminal signal sequence in the exported protein. The signal sequence aids protein export and is cleaved off by a periplasmic signal peptidase when the exported protein reaches the periplasm Aeromonas hydrophila ADP + phosphate
-
 ?
ATP + H2O a signature of the sec-dependent protein transport, by the type II and the type IV secretion, is the presence of a short, about 30 amino acids, mainly hydrophobic amino-terminal signal sequence in the exported protein. The signal sequence aids protein export and is cleaved off by a periplasmic signal peptidase when the exported protein reaches the periplasm Xanthomonas campestris ADP + phosphate
-
 ?
ATP + H2O a signature of the sec-dependent protein transport, by the type II and the type IV secretion, is the presence of a short, about 30 amino acids, mainly hydrophobic amino-terminal signal sequence in the exported protein. The signal sequence aids protein export and is cleaved off by a periplasmic signal peptidase when the exported protein reaches the periplasm Erwinia sp. ADP + phosphate
-
 ?
ATP + H2O a signature of the sec-dependent protein transport, by the type II and the type IV secretion, is the presence of a short, about 30 amino acids, mainly hydrophobic amino-terminal signal sequence in the exported protein. The signal sequence aids protein export and is cleaved off by a periplasmic signal peptidase when the exported protein reaches the periplasm Bordetella pertussis ADP + phosphate
-
 ?
ATP + H2O secreted proteins, their biochemical activity and interaction with host or other proteins, overview Salmonella enterica subsp. enterica serovar Typhimurium ADP + phosphate
-
 ?
ATP + H2O secreted proteins, their biochemical activity and interaction with host or other proteins, overview Pseudomonas aeruginosa ADP + phosphate
-
 ?
ATP + H2O secreted proteins, their biochemical activity and interaction with host or other proteins, overview Pseudomonas syringae ADP + phosphate
-
 ?
ATP + H2O secreted proteins, their biochemical activity and interaction with host or other proteins, overview Erwinia sp. ADP + phosphate
-
 ?
ATP + H2O secreted proteins, their biochemical activity and interaction with host or other proteins, overview Ralstonia solanacearum ADP + phosphate
-
 ?
ATP + H2O secreted proteins, their biochemical activity and interaction with host or other proteins, overview Yersinia sp. ADP + phosphate
-
 ?
ATP + H2O secreted proteins, their biochemical activity and interaction with host or other proteins, overview Shigella flexneri ADP + phosphate
-
 ?
ATP + H2O pathogens use the type III system as a key virulence mechanism Yersinia sp. ADP + phosphate
-
 ?
ATP + H2O pathogens use the type III system as a key virulence mechanism Shigella flexneri ADP + phosphate
-
 ?
ATP + H2O type II secretion is the primary pathway for the secretion of extracellular degradative enzymes by gram-negative bacteria Pseudomonas aeruginosa ADP + phosphate
-
 ?
ATP + H2O type II secretion is the primary pathway for the secretion of extracellular degradative enzymes by gram-negative bacteria Aeromonas hydrophila ADP + phosphate
-
 ?
ATP + H2O type II secretion is the primary pathway for the secretion of extracellular degradative enzymes by gram-negative bacteria Xanthomonas campestris ADP + phosphate
-
 ?
ATP + H2O type II secretion is the primary pathway for the secretion of extracellular degradative enzymes by gram-negative bacteria Erwinia sp. ADP + phosphate
-
 ?
ATP + H2O the two type II secretion systems, SPI-1 and SPI-2 appear to play different roles during pathogenesis, with SPI-1 being required for initial penetration of the intestinal mucosa and SPI-2 necessary for subsequent systemic stages of infection Salmonella enterica subsp. enterica serovar Typhimurium ADP + phosphate
-
 ?
ATP + H2O the type III secretion mechanism enables Yersinia sp. to inject a number of essential virulence determinants into the cytosol of host target cells. The injected proteins appear to interfere with host cell signal transduction pathway and other cellular processes, allowing Yersinia sp. to obstruct the primary immune response and to establish a systemic infaction Yersinia sp. ADP + phosphate
-
 ?

Subunits

Subunits Comment Organism
More
-
 Salmonella enterica subsp. enterica serovar Typhimurium
More
-
 Pseudomonas aeruginosa
More
-
 Xanthomonas campestris
More
-
 Shigella flexneri
More the secretory pathway comprises a number of inner membrane proteins, SecD to SecF, SecY, a cytoplasmic membrane-associated ATPase, SecA, that provides the energy for export, a chaperone, SecB, that binds to presecretory target proteins, and the periplasmic signal peptidase Escherichia coli