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Literature summary for 7.4.2.5 extracted from

  • Geissler, S.; Zwarg, M.; Knütter, I.; Markwardt, F.; Brandsch, M.
    The bioactive dipeptide anserine is transported by human proton-coupled peptide transporters (2010), FEBS J., 277, 790-795.
    View publication on PubMed
Search for more literature for 7.4.2.5

Cloned(Commentary)

Cloned (Comment) Organism
expression in Caco-2 cells and HeLa cells Homo sapiens
expression in spontaneous hypertensive rat kidney proximal tubule cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
anserine inhibits uptake of glycylsarcosine Homo sapiens
anserine inhibits uptake of glycylsarcosine Rattus norvegicus
carnosine inhibits uptake of glycylsarcosine Homo sapiens
carnosine inhibits uptake of glycylsarcosine Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + anserine/out
-
 Homo sapiens ADP + phosphate + anserine/in
-
 ?
ATP + H2O + carnosine/out
-
 Homo sapiens ADP + phosphate + carnosine/in
-
 ?
ATP + H2O + glycylsarcosine/out
-
 Homo sapiens ADP + phosphate + glycylsarcosine/in
-
 ?
additional information using the two-electrode, voltage-clamp technique at Xenopus laevis oocytes, strong hPEPT1-specific inward transport currents are recorded for glycylsarcosine, anserine and carnosine, but not for glycine Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
H+/peptide cotransporter
-
 Homo sapiens
H+/peptide cotransporter
-
 Rattus norvegicus
PepT1
-
 Homo sapiens
PEPT2
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.033
-
 anserine pH 6.0, 22°C Rattus norvegicus
0.65
-
 anserine pH 6.0, 22°C, transfection of HeLa cells Homo sapiens
1.55
-
 anserine pH 6.0, 22°C, transfection of Caco-2 cells Homo sapiens