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Literature summary for 7.4.2.2 extracted from

  • Barthelemy, C.; Barry, A.O.; Twyffels, L.; Andre, B.
    FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition (2017), Sci. Rep., 7, 13816 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information FTY720 (i.e. 2-amino-2-[2-(4-octylphenyl)]-1,3-propanediol hydrochloride or fingolimod) promotes endocytosis of the enzyme in HeLa cells, this is preceded by loss of its transport activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + L-leucine-[L-leucine-binding protein][side 1] Homo sapiens
-
ADP + phosphate + L-leucine[side 2] + [L-leucine-binding protein][side 1]
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + L-leucine-[L-leucine-binding protein][side 1]
-
Homo sapiens ADP + phosphate + L-leucine[side 2] + [L-leucine-binding protein][side 1]
-
?

Synonyms

Synonyms Comment Organism
Lat1
-
Homo sapiens
SLC7A5
-
Homo sapiens