Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.4.2.12 extracted from

  • Chonoles Imlay, K.R.; Korshunov, S.; Imlay, J.A.
    Physiological roles and adverse effects of the two cystine importers of Escherichia coli (2015), J. Bacteriol., 197, 3629-3644 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.4.2.12

Inhibitors

Inhibitors Comment Organism Structure
selenocystine competitively blocks cystine import by enzyme form YdjN Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + D-cystine-[cystine-binding protein](side 1) Escherichia coli
-
 ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
-
 ?
ATP + H2O + L-cystine-[cystine-binding protein](side 1) Escherichia coli
-
 ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:D-cystine-grown cell
-
 Escherichia coli
-
culture condition:L-cystine-grown cell
-
 Escherichia coli
-
culture condition:sulfate-grown cell
-
 Escherichia coli
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + D-cystine-[cystine-binding protein](side 1)
-
 Escherichia coli ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
-
 ?
ATP + H2O + diaminopimelate-[diaminopimelate-binding protein](side 1)
-
 Escherichia coli ADP + phosphate + diaminopimelate(side 2) + [diaminopimelate-binding protein](side 1)
-
 ?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
-
 Escherichia coli ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
-
 ?

Synonyms

Synonyms Comment Organism
cystine importer
-
 Escherichia coli
FliY-YecSC
-
 Escherichia coli
tcyJLN
-
 Escherichia coli
tcyP
-
 Escherichia coli
YdjN
-
 Escherichia coli

Expression

Organism Comment Expression
Escherichia coli the enzyme is strongly induced by the regulon CysB response to sulfur scarcity up

General Information

General Information Comment Organism
metabolism enzyme form FliY-YecSC is essential for import of trace cystine, whereas enzyme form YdjN is the predominant importer when cystine is more abundant. YdjN is responsible for the rapid cystine import and H2O2 sensitivity of Escherichia coli that has been pre-grown in sulfate medium, but the rapid transport and H2O2 sensitivity are absent if cells have been pre-grown in cystine medium Escherichia coli