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Literature summary for 7.4.2.11 extracted from

  • Yang, J.G.; Rees, D.C.
    The allosteric regulatory mechanism of the Escherichia coli MetNI methionine ATP binding cassette (ABC) transporter (2015), J. Biol. Chem., 290, 9135-9140 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21-Gold (lambdaDE3) cells Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
ADP competitive inhibitor Escherichia coli
L-methionine noncompetitive inhibitor of enzyme ATPase activity. The uptake of external methionine is repressed by the level of the internal L-methionine pool (transinhibition) Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.33
-
ATP at pH 7.5 and 33°C Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Escherichia coli 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + D-methionine-[methionine-binding protein][side 1] Escherichia coli
-
ADP + phosphate + D-methionine[side 2] + [methionine-binding protein][side 1]
-
?
ATP + H2O + L-methionine-[methionine-binding protein][side 1] Escherichia coli
-
ADP + phosphate + L-methionine[side 2] + [methionine-binding protein][side 1]
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
HisTrap column chromatography and Superdex S200 gel filtration Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + D-methionine-[methionine-binding protein][side 1]
-
Escherichia coli ADP + phosphate + D-methionine[side 2] + [methionine-binding protein][side 1]
-
?
ATP + H2O + L-methionine-[methionine-binding protein][side 1]
-
Escherichia coli ADP + phosphate + L-methionine[side 2] + [methionine-binding protein][side 1]
-
?

Synonyms

Synonyms Comment Organism
methionine ATP binding cassette transporter
-
Escherichia coli
methionine importer
-
Escherichia coli
MetNI
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.041
-
ADP at pH 7.5 and 33°C Escherichia coli
0.041
-
L-methionine at pH 7.5 and 33°C Escherichia coli

General Information

General Information Comment Organism
metabolism the enzyme regulates intracellular methionine concentrations Escherichia coli