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Literature summary for 7.4.2.1 extracted from

  • Ruiz, J.; Haneburger, I.; Jung, K.
    Identification of ArgP and Lrp as transcriptional regulators of lysP, the gene encoding the specific lysine permease of Escherichia coli (2011), J. Bacteriol., 193, 2536-2548.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + L-lysine/out Escherichia coli
-
 ADP + phosphate + L-lysine/in
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 diverse strains, gene lysP
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + L-lysine/out
-
 Escherichia coli ADP + phosphate + L-lysine/in
-
 ?

Synonyms

Synonyms Comment Organism
lysine permease
-
 Escherichia coli
lysine-specific transporter
-
 Escherichia coli
LysP
-
 Escherichia coli

General Information

General Information Comment Organism
metabolism LysR-type ArgP and global regulator Lrp are transcriptional regulators of gene lysP, which is also regulated by the concentration of exogenous available lysine. Lysine-loaded ArgP and arginine-loaded ArgP compete at the lysP promoter. ArgP binds to the lysP promoter/control region at a T-N11-A motif in the presence and absence of lysine. Lysine-loaded ArgP prevents lysP transcription at the promoter clearance step and is a major regulator of lysP expression, Lrp modulates lysP transcription under lysine-limiting conditions by direct binding to its control region Escherichia coli