Literature summary for 7.4.2.1 extracted from

Rubio-Texeira, M.; Kaiser, C.A.
Amino acids regulate retrieval of the yeast general amino acid permease from the vacuolar targeting pathway (2006), Mol. Biol. Cell, 17, 3031-3050.

Search for more literature for 7.4.2.1

Application

Application	Comment	Organism
additional information	role of ubiquitination appears to be a signal for delivery of Gap1p to the multivesicular endosome, whereas amino acid abundance appears to control the cycling of Gap1p from the multivesicular endosome to the plasma membrane, Gap1p recycling does not depend on other known pathways for recycling proteins from the endosome to Golgi compartments	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
additional information	mutants defective in Gap1p polyubiquitination and class E vps mutants show highly increased levels of active Gap1p, but only class E vps mutants can respond normally to high external and internal amino acid concentrations by redirecting Gap1p away from the plasma membrane to the vacuolar targeting pathway, LST4 or LST7 mutations block Gap1p traffic to the plasma membrane	Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	cycling of Gap1p-GFP to the plasma membrane is blocked by high amino acid concentrations	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
additional information	multivesicular endosome	Saccharomyces cerevisiae	-	-
plasma membrane	at low amino acid concentrations	Saccharomyces cerevisiae	5886	-
vacuole	at high amino acid concentrations, Gap1p-GFP is delivered to the vacuolar interior by the multivesicular endosome pathway in wild-type cells	Saccharomyces cerevisiae	5773	-

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	strains isogenic with S288C	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
Gap1p	-	Saccharomyces cerevisiae
general amino acid permease	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)