Literature summary for 7.4.2.1 extracted from

Liu, C.E.; Liu, P.Q.; Wolf, A.; Lin, E.; Ferro-Luzzi Ames, G.
Both lobes of the soluble receptor of the periplasmic histidine permease, an ABC transporter (traffic ATPase), interact with the membrane-bound complex (1999), J. Biol. Chem., 274, 739-747.

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Activating Compound

Activating Compound	Comment	Organism	Structure
histidine-binding protein	the histidine-binding protein HisJ, interacts with the membrane-bound complex HisQMP2 and stimulates its ATPase activity, which results in histidine translocation. HisJ provides some additional essential function in translocation that is independent of the stimulation of ATP hydrolysis. HisJ has different optimal conformations for signaling and for translocation	Salmonella enterica subsp. enterica serovar Typhimurium

Protein Variants

Protein Variants	Comment	Organism
D149A	mutation in histidine binding subunit HisJ, mutant protein is capable of interacting with HisQMP2 although at a much reduced level	Salmonella enterica subsp. enterica serovar Typhimurium
D149N	mutation in histidine binding subunit HisJ, mutant protein is capable of interacting with HisQMP2 although at a much reduced level	Salmonella enterica subsp. enterica serovar Typhimurium
P172T	-	Salmonella enterica subsp. enterica serovar Typhimurium
R154D	mutation in histidine binding subunit HisJ, binds His as well as the wild type, defective in transport	Salmonella enterica subsp. enterica serovar Typhimurium
R154S	mutation in histidine binding subunit HisJ, binds His as well as the wild type, defective in transport	Salmonella enterica subsp. enterica serovar Typhimurium
T205M	increased intrinsic ATPase activity without HisJ	Salmonella enterica subsp. enterica serovar Typhimurium

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica subsp. enterica serovar Typhimurium	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
HisQMP2	Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + His/out	-	Salmonella enterica subsp. enterica serovar Typhimurium	ADP + phosphate + His/in	-	?

Subunits

Subunits	Comment	Organism
More	the histidine-binding protein HisJ, interacts with the membrane-bound complex HisQMP2 and stimulates its ATPase activity, which results in histidine translocation. HisJ provides some additional essential function in translocation that is independent of the stimulation of ATP hydrolysis. HisJ has different optimal conformations for signaling and for translocation	Salmonella enterica subsp. enterica serovar Typhimurium

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Release 2023.1 (January 2023)