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Literature summary for 7.3.2.1 extracted from

  • Kelliher, J.; Radin, J.; Grim, K.; Solorzano, P.; Degnan, P.; Kehl-Fie, T.
    Acquisition of the phosphate transporter NptA enhances Staphylococcus aureus pathogenesis by improving phosphate uptake in divergent environments (2018), Infect. Immun., 86, e00631-37.
    View publication on PubMed
Search for more literature for 7.3.2.1

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus A0A290QKL9
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Staphylococcus aureus Newman A0A290QKL9
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Synonyms

Synonyms Comment Organism
CNH35_00300
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 Staphylococcus aureus
Na/Pi cotransporter
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 Staphylococcus aureus
NptA
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 Staphylococcus aureus

Expression

Organism Comment Expression
Staphylococcus aureus is induced by phosphate limitation up

General Information

General Information Comment Organism
physiological function Staphylococcus aureus possesses three distinct Pi transporters: PstSCAB, PitA, and NptA. The loss of a single transporter does not affect S. aureus. Disruption of any two systems significantly reduces phosphate accumulation and growth in divergent environments. In a systemic mouse model of disease, loss of any one transporter does not decrease staphylococcal virulence. Loss of NptA in conjunction with either PstSCAB or PitA significantly reduces the ability of S. aureus to cause infection Staphylococcus aureus