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Literature summary for 7.3.2.1 extracted from

  • Weinman, E.J.; Steplock, D.; Zhang, Y.; Biswas, R.; Bloch, R.J.; Shenolikar, S.
    Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport (2010), J. Biol. Chem., 285, 25134-25138.
    View publication on PubMed
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Localization

Localization Comment Organism GeneOntology No. Textmining
apical plasma membrane
-
 Homo sapiens 16324
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) interacts with C-terminal end of sodium-dependent phosphate transporter 2a ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) interacts with C-terminal end of sodium-dependent phosphate transporter 2a Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Npt2a
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 Homo sapiens
sodium-dependent phosphate transporter 2a
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 Homo sapiens

General Information

General Information Comment Organism
physiological function phosphorylation of the sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) plays a key role in the regulation of renal phosphate transport by parathyroid hormone and dopamine. The substitution of serine for aspartic acid (S77D) in the PDZ I domain of NHERF-1 decreases the binding affinity to Npt2a Homo sapiens