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Literature summary for 7.2.4.3 extracted from

  • Galivan, J.H.; Allen, S.H.G.
    Methylmalonyl-CoA decarboxylase: partial purification and enzymatic properties (1968), Arch. Biochem. Biophys., 126, 838-847.
    View publication on PubMed
Search for more literature for 7.2.4.3

Inhibitors

Inhibitors Comment Organism Structure
(S)-methylmalonyl-CoA substrate inhibition above 0.014 mM Veillonella parvula
Avidin
-
 Veillonella parvula
butyryl-CoA
-
 Veillonella parvula
CoA
-
 Veillonella parvula
glutaryl-CoA
-
 Veillonella parvula
malonyl-CoA
-
 Veillonella parvula
PCMB
-
 Veillonella parvula
succinyl-CoA
-
 Veillonella parvula

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002
-
 (S)-methylmalonyl-CoA
-
 Veillonella parvula

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
275000 300000 sucrose density gradient centrifugation Veillonella parvula

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2] Veillonella parvula the enzyme is responsible for the formation of the propionate moiety in the fermentation of lactate and the decarboxylation of succinate propanoyl-CoA + CO2 + Na+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Veillonella parvula
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Veillonella parvula

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2] irreversible Veillonella parvula propanoyl-CoA + CO2 + Na+[side 2]
-
 ?
(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2] the enzyme is responsible for the formation of the propionate moiety in the fermentation of lactate and the decarboxylation of succinate Veillonella parvula propanoyl-CoA + CO2 + Na+[side 2]
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5 7
-
 Veillonella parvula

Cofactor

Cofactor Comment Organism Structure
biotin prosthetic group Veillonella parvula