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Literature summary for 7.2.2.9 extracted from

  • White, C.; Lee, J.; Kambe, T.; Fritsche, K.; Petris, M.J.
    A role for the ATP7A copper-transporting ATPase in macrophage bactericidal activity (2009), J. Biol. Chem., 284, 33949-33956.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.9

Protein Variants

Protein Variants Comment Organism
additional information ATP7A silencing by stable transfection of RAW-264.7 cells with ATP7A RNAi Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
ebselen
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi membrane perinuclear location of ATP7A. IFN-gamma activation of macrophages is associated with partial redistribution of ATP7A to the phagolysosomal compartment, IFN-gamma triggers the trafficking of ATP7A Mus musculus 139
-
additional information IFN-gamma and lipopolysaccharides stimulate copper-dependent ATP7A trafficking to post-Golgi vesicles that overlap with the phagosome, overview Mus musculus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Mus musculus
-
 ADP + phosphate + Cu2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 gene ATP7A
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Mus musculus ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP7A
-
 Mus musculus
copper-transporting ATPase
-
 Mus musculus

General Information

General Information Comment Organism
additional information Escherichia coli survival is dependent on ATP7A expression in murine RAW-264.7 macrophages. Baterial survival is significantly increased in ATP7A-depleted cells compared with control cells, and copper pretreatment of ATP7A-depleted cells restores bactericidal activity to control levels, overview. Copper enhances the bactericidal activity of macrophages Mus musculus
physiological function ATP7A-dependent copper transport is required for bactericidal activity of RAW-264.7 macrophages Mus musculus