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Literature summary for 7.2.2.9 extracted from
- Alternative splicing of the Menkes copper Atpase (Atp7a) transcript in the rat intestinal epithelium (2009), Am. J. Physiol. Gastrointest. Liver Physiol., 297, G695-G707.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene ATP7A, genetic mapping and expression analysis of splicing variants, overview | Homo sapiens |
| gene ATP7A, genetic mapping and expression analysis of splicing variants, overview | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | 97 kDa variant | Homo sapiens | 5829 | - |
| cytosol | 97 kDa variant | Rattus norvegicus | 5829 | - |
| additional information | immunohistochemic localization analysis, overview | Homo sapiens | - |
- |
| additional information | immunohistochemic localization analysis, overview | Rattus norvegicus | - |
- |
| nucleus | 64 kDa variant | Homo sapiens | 5634 | - |
| nucleus | 64 kDa variant | Rattus norvegicus | 5634 | - |
| plasma membrane | 97 kDa variant | Homo sapiens | 5886 | - |
| plasma membrane | 97 kDa variant | Rattus norvegicus | 5886 | - |
| trans-Golgi network | - |
Homo sapiens | 5802 | - |
| trans-Golgi network | - |
Rattus norvegicus | 5802 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens |  |
| Mg2+ | required | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 64000 | - |
x * 97000, splicing variant in cytosol and plasma membrane, SDS-PAGE, x * 64000, splicing variant in nucleus, SDS-PAGE | Homo sapiens |
| 64000 | - |
x * 97000, splicing variant in cytosol and plasma membrane, SDS-PAGE, x * 64000, splicing variant in nucleus, SDS-PAGE | Rattus norvegicus |
| 97000 | - |
x * 97000, splicing variant in cytosol and plasma membrane, SDS-PAGE, x * 64000, splicing variant in nucleus, SDS-PAGE | Homo sapiens |
| 97000 | - |
x * 97000, splicing variant in cytosol and plasma membrane, SDS-PAGE, x * 64000, splicing variant in nucleus, SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Cu2+/in | Homo sapiens | - |
ADP + phosphate + Cu2+/out | - |
? | |
| ATP + H2O + Cu2+/in | Rattus norvegicus | - |
ADP + phosphate + Cu2+/out | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
gene ATP7A | - |
| Rattus norvegicus | - |
gene ATP7A, three splicing variants | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Caco-2 cell | - |
Homo sapiens | - |
| IEC-6 cell | - |
Rattus norvegicus | - |
| intestinal epithelium | - |
Homo sapiens | - |
| intestinal epithelium | - |
Rattus norvegicus | - |
| intestine | - |
Homo sapiens | - |
| intestine | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Cu2+/in | - |
Homo sapiens | ADP + phosphate + Cu2+/out | - |
? | |
| ATP + H2O + Cu2+/in | - |
Rattus norvegicus | ADP + phosphate + Cu2+/out | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 97000, splicing variant in cytosol and plasma membrane, SDS-PAGE, x * 64000, splicing variant in nucleus, SDS-PAGE | Homo sapiens |
| ? | x * 97000, splicing variant in cytosol and plasma membrane, SDS-PAGE, x * 64000, splicing variant in nucleus, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ATP7A | - |
Homo sapiens |
| ATP7A | - |
Rattus norvegicus |
| copper ATPase | - |
Homo sapiens |
| copper ATPase | - |
Rattus norvegicus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | iron deprivation induces all three splicing variants 5-7fold | up |
| Rattus norvegicus | iron deprivation induces all three splicing variants 5-7fold | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | gene regulation of ATP7A by iron deprivation | Homo sapiens |
| metabolism | gene regulation of ATP7A by iron deprivation | Rattus norvegicus |
| additional information | mutation of ATP7A is involved in Menkes disease, a severe infantile-onset neurodegenerative disorder | Homo sapiens |
| additional information | mutation of ATP7A is involved in Menkes disease, a severe infantile-onset neurodegenerative disorder | Rattus norvegicus |
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Release 2023.1 (January 2023)
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