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Literature summary for 7.2.2.9 extracted from

  • Barnes, N.; Bartee, M.Y.; Braiterman, L.; Gupta, A.; Ustiyan, V.; Zuzel, V.; Kaplan, J.H.; Hubbard, A.L.; Lutsenko, S.
    Cell-specific trafficking suggests a new role for renal ATP7B in the intracellular copper storage (2009), Traffic, 10, 767-779.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.9

Cloned(Commentary)

Cloned (Comment) Organism
DNA sequence and genetic structure analysis of ATP7B from renal and hepatic tissue and comparison, recombinant ATP7B expressed in renal cells is similar to hepatic protein in size and trafficking, ATP7B lacking the exon 1 sequence shows cell-specific trafficking in polarized renal and hepatic cells, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Homo sapiens kidney-specific regulation of ATP7B, unlike ATP7A, or hepatic ATP7B, which traffics from the TGN to export copper, renal ATP7B does not traffic and therefore is unlikely to mediate copper export. Role for renal ATP7B in intracellular copper storage ADP + phosphate + Cu2+/out
-
 ?
additional information Homo sapiens inactivation of Cu-ATPases ATP7A and ATP7B causes Menkes disease and Wilson disease, respectively. In Menkes disease, copper accumulates in kidneys and causes tubular damage, indicating that the renal ATP7B does not compensate for the loss of ATP7A function, copper efflux by ATP7A does not contribute to the lack of trafficking response by ATP7B ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information ATP7B in Hep-G2 and HEK-293 cells differ in size, but not in post-translational modifications Homo sapiens
phosphoprotein ATP7B is phosphorylated in HEK-293 and Hep-G2 cells, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell ATP7A and ATP7B Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
hepatocyte primary and cultured Homo sapiens
-
kidney
-
 Homo sapiens
-
kidney ATP7A and ATP7B Homo sapiens
-
liver ATP7A and ATP7B Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Homo sapiens ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in kidney-specific regulation of ATP7B, unlike ATP7A, or hepatic ATP7B, which traffics from the TGN to export copper, renal ATP7B does not traffic and therefore is unlikely to mediate copper export. Role for renal ATP7B in intracellular copper storage Homo sapiens ADP + phosphate + Cu2+/out
-
 ?
additional information inactivation of Cu-ATPases ATP7A and ATP7B causes Menkes disease and Wilson disease, respectively. In Menkes disease, copper accumulates in kidneys and causes tubular damage, indicating that the renal ATP7B does not compensate for the loss of ATP7A function, copper efflux by ATP7A does not contribute to the lack of trafficking response by ATP7B Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More ATP7B from HEK-293 and Hep-G2 cells have different electrophoretic properties, ATP7B in Hep-G2 and HEK-293 cells differ in size, but not in post-translational modifications Homo sapiens

Synonyms

Synonyms Comment Organism
ATP7A
-
 Homo sapiens
ATP7B
-
 Homo sapiens
Cu-ATPase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 copper transport assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 copper transport assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens