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Literature summary for 7.2.2.9 extracted from

  • Kobayashi, Y.; Kuroda, K.; Kimura, K.; Southron-Francis, J.L.; Furuzawa, A.; Kimura, K.; Iuchi, S.; Kobayashi, M.; Taylor, G.J.; Koyama, H.
    Amino acid polymorphisms in strictly conserved domains of a P-type ATPase HMA5 are involved in the mechanism of copper tolerance variation in Arabidopsis (2008), Plant Physiol., 148, 969-980.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
genetic architecture of Cu tolerance, overview Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information complementation assays of the ccc2 mutant of yeast using chimeric HMA5 proteins, a dysfunctional HMA5 allele is identified in Chisdra-2, which shows Cu sensitivity and low capacity of Cu translocation from roots to shoots, a unique amino acid substitution of Chisdra-2 occurs in another strictly conserved domain, CPC(x)6P, where the latter proline is replaced with leucine. The homozygous HMA5-KO line SALK_040252, carrying a T-DNA insertion at the first intron, shows hypersensitivity to Cu while showing similar growth to the wild type Col-0 in control solution Arabidopsis thaliana
N923T mutation in the Cvi allele in the tightly conserved domain N(x)6YN(x)4P, is a cause of dysfunction of the Cvi HMA5 allele Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Arabidopsis thaliana
-
 ADP + phosphate + Cu2+/out
-
 ?
additional information Arabidopsis thaliana the variation in Cu tolerance of Arabidopsis is regulated by the functional integrity of the Cu-translocating ATPase, HMA5, and in particular the amino acid sequence in several strictly conserved motifs, molecular mechanism of Cu tolerance, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9SH30
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Arabidopsis thaliana ADP + phosphate + Cu2+/out
-
 ?
additional information the variation in Cu tolerance of Arabidopsis is regulated by the functional integrity of the Cu-translocating ATPase, HMA5, and in particular the amino acid sequence in several strictly conserved motifs, molecular mechanism of Cu tolerance, overview Arabidopsis thaliana ?
-
 ?

Synonyms

Synonyms Comment Organism
Cu-transporting P1B-1-type ATPase
-
 Arabidopsis thaliana
HMA5
-
 Arabidopsis thaliana
moe HMA5 belongs to a large family of genes encoding P1B-type cation-transporting ATPases Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Arabidopsis thaliana