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Literature summary for 7.2.2.9 extracted from

  • Ke, B.X.; Llanos, R.M.; Mercer, J.F.
    ATP7A transgenic and nontransgenic mice are resistant to high copper exposure (2008), J. Nutr., 138, 693-697.
    View publication on PubMed
Search for more literature for 7.2.2.9

Protein Variants

Protein Variants Comment Organism
additional information transgenic C57BL/6J mice overexpressing the human ATP7A from the chicken beta-actin composite promoter CAG causes disturbances in Cu homeostasis, with depletion of Cu in some tissues, especially the heart. Cu exposure results in partial restoration of heart Cu concentrations in male transgenic mice. Despite the extended period of Cu exposure, Cu concentrations in the liver remain relatively unaffected, with a significant increase in male nontransgenic mice. In transgenic mice, expression levels of ATP7A and other Cu homeostasis proteins, as well as intracellular localization of ATP7A in various tissues are not significantly affected by Cu exposure Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
additional information intracellular localization of ATP7A in various tissues is not affected by Cu exposure Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Homo sapiens ATP7A, a copper-transporting P-type ATPase, plays an important role in Cu homeostasis and is affected in Menkes disease ADP + phosphate + Cu2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
additional information expression levels of ATP7A and other Cu homeostasis proteins are not significantly affected by Cu exposure Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Homo sapiens ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in ATP7A, a copper-transporting P-type ATPase, plays an important role in Cu homeostasis and is affected in Menkes disease Homo sapiens ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP7A
-
 Homo sapiens
copper-transporting P-type ATPase
-
 Homo sapiens
Cu-transporting P-type ATPase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens