Cloned (Comment) | Organism |
---|---|
Drosophila transformation vector pW8 used, generation of transgenic lines and construction of a EYFP-DmATP7 fusion protein for localization studies described | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | at or proximal to basolateral plasma membrane of midgut cells | Drosophila melanogaster | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | Drosophila melanogaster | - |
ADP + phosphate + Cu2+/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | Q9VYT4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
midgut | larval stage, copper-inducible | Drosophila melanogaster | - |
neuron | main neurons of leg, wing margin, labellum, maxillary palps and third antennal segment | Drosophila melanogaster | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
enhancer element with sufficient regulatory information to rescue DmATP7 mutant flies to adulthood, regulation of DmATP7 expression shown to be not used to limit copper absorption in toxic copper conditions, functional role for copper transport in neuronal tissues indicated, role for export of copper from midgut cells supported by localization studies | Drosophila melanogaster |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | - |
Drosophila melanogaster | ADP + phosphate + Cu2+/out | - |
? | |
ATP + H2O + Cu2+/in | neuronal and copper-inducible expression of DmATP7 reporter gene, role for DmATP7 in export of copper from midgut cells and for copper transport in neuronal tissues | Drosophila melanogaster | ADP + phosphate + Cu2+/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATP7 | - |
Drosophila melanogaster |