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Literature summary for 7.2.2.9 extracted from

  • Bartee, M.Y.; Lutsenko, S.
    Hepatic copper-transporting ATPase ATP7B: function and inactivation at the molecular and cellular level (2007), Biometals, 20, 627-637.
    View publication on PubMed
Search for more literature for 7.2.2.9

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi trans face
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Homo sapiens
-
 ADP + phosphate + Cu2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P35670
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 immunocytochemistry experiments, co-localization studies performed, consequences of ATP7B inactivation in knock-out mice analyzed, studies on Wilson disease causing mutation H1069Q summarized Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Homo sapiens ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in role of ATP7B in liver analyzed, essential for delivery of copper to ceruloplasmin in the biosynthetic pathway and required for copper export into the bile Homo sapiens ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP7B
-
 Homo sapiens
Wilson disease protein
-
 Homo sapiens