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Literature summary for 7.2.2.9 extracted from

  • Lutsenko, S.; Gupta, A.; Burkhead, J.L.; Zuzel, V.
    Cellular multitasking: The dual role of human Cu-ATPases in cofactor delivery and intracellular copper balance (2008), Arch. Biochem. Biophys., 476, 22-32.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.9

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane trafficking in polarized cells Homo sapiens 16020
-
membrane trafficking in polarized cells summarized Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Homo sapiens
-
 ADP + phosphate + Cu2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P35670
-
-
Homo sapiens Q04656
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell model for the ATP7A trafficking in enterocytes Homo sapiens
-
Hep-G2 cell localization of ATP7B in polarized hepatocytes Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 structural features and major functional domains of human copper-ATPases shown, transport mechanism and regulation of catalytic activity, localization and trafficking in polarized cells, role metal-binding subdomains, comparison with orthologs from other species Homo sapiens
additional information
-
 structural features and major functional domains of human copper-ATPases, transport mechanism and regulation of catalytic activity, localization and trafficking in polarized cells, role metal-binding subdomains, comparison with orthologs from other species Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Homo sapiens ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in function and regulatory mechanisms acting on human copper-ATPases ATP7A and ATP7B Homo sapiens ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP7A
-
 Homo sapiens
ATP7B
-
 Homo sapiens