Literature summary for 7.2.2.9 extracted from

Achila, D.; Banci, L.; Bertini, I.; Bunce, J.; Ciofi-Baffoni, S.; Huffman, D.L.
Structure of human Wilson protein domains 5 and 6 and their interplay with domain 4 and the copper chaperone HAH1 in copper uptake (2006), Proc. Natl. Acad. Sci. USA, 103, 5729-5734.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P35670	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Cu+/in	Wilson protein domains 5 and 6 and their interplay with domain 4 and the copper chaperone HAH1 in copper uptake. Wilson protein domain 4 and domain 2 are two acceptors of Cu(I) from the cytosolic metallochaperone HAH1, which then somehow route copper to Wilson protein domain 5 and 6, before the ATP-driven transport of copper across the vesicular membrane	Homo sapiens	ADP + phosphate + Cu+/out	-	?

Synonyms

Synonyms	Comment	Organism
Wilson protein	-	Homo sapiens

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Release 2023.1 (January 2023)