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Literature summary for 7.2.2.9 extracted from

  • Krajacic, P.; Qian, Y.; Hahn, P.; Dentchev, T.; Lukinova, N.; Dunaief, J.L.
    Retinal localization and copper-dependent relocalization of the Wilson and Menkes disease proteins (2006), Invest. Ophthalmol. Vis. Sci., 47, 3129-3134.
    View publication on PubMed
Search for more literature for 7.2.2.9

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm within ARPE-19 cell the Wilson disease protein shows a perinuclear and cytoplasmic distribution Homo sapiens 5737
-
perinuclear space within ARPE-19 cell the Wilson disease protein shows a perinuclear and cytoplasmic distribution Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Homo sapiens because the Wilson protein delivers copper to the ferroxidase ceruloplasminm in the liver, it is likely that the Wilson and/or Menkes proteins provide copper to ceruloplasmin made in the retinal pigment epithelium ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in Mus musculus because the Wilson protein delivers copper to the ferroxidase ceruloplasminm in the liver, it is likely that the Wilson and/or Menkes proteins provide copper to cerulopliasmin made in the retinal pigment epithelium ADP + phosphate + Cu2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P35670
-
-
Mus musculus Q64430
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ARPE-19 cell
-
 Homo sapiens
-
retina
-
 Homo sapiens
-
retina
-
 Mus musculus
-
retinal pigment epithelium
-
 Homo sapiens
-
retinal pigment epithelium
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Homo sapiens ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in
-
 Mus musculus ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in because the Wilson protein delivers copper to the ferroxidase ceruloplasminm in the liver, it is likely that the Wilson and/or Menkes proteins provide copper to ceruloplasmin made in the retinal pigment epithelium Homo sapiens ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in because the Wilson protein delivers copper to the ferroxidase ceruloplasminm in the liver, it is likely that the Wilson and/or Menkes proteins provide copper to cerulopliasmin made in the retinal pigment epithelium Mus musculus ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
Menkes disease protein
-
 Mus musculus
Wilson disease protein
-
 Homo sapiens