Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
pericanalicular vesicle | in HepG2 cells, elevated copper levels stimulates trafficking of ATP7B to pericanalicular vesicles. Mutations of an endocytic retrieval signal in ATP7B cause the protein to constitutively localize to vesicles and not to plasma membrane. The vesicular compartment is the final trafficking destination for ATP7B | Homo sapiens | 33675 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu | in HepG2 cells, elevated copper levels stimulates trafficking of ATP7B to pericanalicular vesicles. Mechanism of biliary copper excretion involves ATP7B-mediated vesicular sequestration of copper rather than direct copper translocation across the canalicular membrane | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P35670 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ATP7B | - |
Homo sapiens |