Literature summary for 7.2.2.9 extracted from

Saito, T.; Okabe, M.; Hosokawa, T.; Kurasaki, M.; Hata, A.; Endo, F.; Nagano, K.; Matsuda, I.; Urakami, K.; Saito, K.
Immunohistochemical determination of the Wilson copper-transporting P-type ATPase in the brain tissue of the rat (1999), Neurosci. Lett., 266, 13-16.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + Cu2+/in	Rattus norvegicus	in normal conditions ATP7B regulates Cu homeostasis and biosynthesis of holo cuproenzymes and cuproenzyme-related neurotransmission in the brain regions. Neurotoxicity due to abnormal copper accumulation or irregular regulation of cuproenzymes in the critical brain regions by mutation of the ATP7B gene leads to neurological dysfunctions of Wilson disease	ADP + phosphate + Cu2+/out	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	intensely detected in neuronal cells of the hippocampal formation, olfactory bulbs, cerebellum, cerebral cortex and nuclei in the brainstem	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Cu2+/in	-	Rattus norvegicus	ADP + phosphate + Cu2+/out	-	?
ATP + H2O + Cu2+/in	in normal conditions ATP7B regulates Cu homeostasis and biosynthesis of holo cuproenzymes and cuproenzyme-related neurotransmission in the brain regions. Neurotoxicity due to abnormal copper accumulation or irregular regulation of cuproenzymes in the critical brain regions by mutation of the ATP7B gene leads to neurological dysfunctions of Wilson disease	Rattus norvegicus	ADP + phosphate + Cu2+/out	-	?

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Release 2023.1 (January 2023)