Literature summary for 7.2.2.2 extracted from

Mielniczki-Pereira, A.A.; Schuch, A.Z.; Bonatto, D.; Cavalcante, C.F.; Vaitsman, D.S.; Riger, C.J.; Eleutherio, E.C.; Henriques, J.A.
The role of the yeast ATP-binding cassette Ycf1p in glutathione and cadmium ion homeostasis during respiratory metabolism (2008), Toxicol. Lett., 180, 21-27.

Search for more literature for 7.2.2.2

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	N-acetylcysteine, a precursor of glutathione, induces the enzyme expression, restoring the expression in presence of Cd2+	Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment)	Organism
gene YCF1, semiquantitative expression analysis in absence and presence of Cd2+, overview	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
additional information	increased accumulation of GSH in the ycf1 deletion strain during respiratory metabolism	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + Cd2+/in	Saccharomyces cerevisiae	Cd2+ is a toxic environmental contaminant for biological systems, which can form complexes with reduced glutathione, and thus alter the intracellular redox state. In Saccharomyces cerevisiae, bis(glutathionato)cadmium, Cd-[GS]2, complexes can be removed from the cytosol and transported into the vacuole by a glutathione-conjugated pump, Ycf1p, which plays a role in Cd2+ detoxi?cation during respiratory metabolism and is correlated with the glutathione homeostasis, overview	ADP + phosphate + Cd2+/out	-	?
ATP + H2O + Cd2+/in	Saccharomyces cerevisiae BY4741	Cd2+ is a toxic environmental contaminant for biological systems, which can form complexes with reduced glutathione, and thus alter the intracellular redox state. In Saccharomyces cerevisiae, bis(glutathionato)cadmium, Cd-[GS]2, complexes can be removed from the cytosol and transported into the vacuole by a glutathione-conjugated pump, Ycf1p, which plays a role in Cd2+ detoxi?cation during respiratory metabolism and is correlated with the glutathione homeostasis, overview	ADP + phosphate + Cd2+/out	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	gene YCF1	-
Saccharomyces cerevisiae BY4741	-	gene YCF1	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Cd2+/in	-	Saccharomyces cerevisiae	ADP + phosphate + Cd2+/out	-	?
ATP + H2O + Cd2+/in	Cd2+ is a toxic environmental contaminant for biological systems, which can form complexes with reduced glutathione, and thus alter the intracellular redox state. In Saccharomyces cerevisiae, bis(glutathionato)cadmium, Cd-[GS]2, complexes can be removed from the cytosol and transported into the vacuole by a glutathione-conjugated pump, Ycf1p, which plays a role in Cd2+ detoxi?cation during respiratory metabolism and is correlated with the glutathione homeostasis, overview	Saccharomyces cerevisiae	ADP + phosphate + Cd2+/out	-	?
ATP + H2O + Cd2+/in	-	Saccharomyces cerevisiae BY4741	ADP + phosphate + Cd2+/out	-	?
ATP + H2O + Cd2+/in	Cd2+ is a toxic environmental contaminant for biological systems, which can form complexes with reduced glutathione, and thus alter the intracellular redox state. In Saccharomyces cerevisiae, bis(glutathionato)cadmium, Cd-[GS]2, complexes can be removed from the cytosol and transported into the vacuole by a glutathione-conjugated pump, Ycf1p, which plays a role in Cd2+ detoxi?cation during respiratory metabolism and is correlated with the glutathione homeostasis, overview	Saccharomyces cerevisiae BY4741	ADP + phosphate + Cd2+/out	-	?

Synonyms

Synonyms	Comment	Organism
Ycf1p	-	Saccharomyces cerevisiae

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Saccharomyces cerevisiae

Expression

Organism	Comment	Expression
Saccharomyces cerevisiae	the expression of gene YFC1 is downregulated in presence of Cd2+, which affects the YFC1 promoter	down

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Release 2023.1 (January 2023)