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Literature summary for 7.2.2.2 extracted from
- Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration (2009), J. Biol. Chem., 284, 354-362.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Schizosaccharomyces pombe | Drosophila melanogaster |
| phylogenetic analysis | Schizosaccharomyces pombe |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | heterologously expressed DmHMT-1 suppresses the Cd2+ hypersensitivity of Schizosaccharomyces pombe hmt-1 mutants and localizes to the vacuolar membrane but does not transport Cd-PCc, phenotype, overview | Drosophila melanogaster |
| additional information | SpHMT-1-deficient cells are hypersensitive to Cd2+, but not to Hg2+ or As3+, heterologously expressed Drosophila melanogaster HMT-1 suppresses the Cd2+ hypersensitivity of Schizosaccharomyces pombe hmt-1 mutants and localizes to the vacuolar membrane but does not transport Cd-PCc, overview | Schizosaccharomyces pombe |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| vacuolar membrane | - |
Schizosaccharomyces pombe | 5774 | - |
| vacuolar membrane | - |
Drosophila melanogaster | 5774 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 97900 | - |
x * 97900 | Drosophila melanogaster |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Cd2+/in | Drosophila melanogaster | ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration | ADP + phosphate + Cd2+/out | - |
? |  |
| ATP + H2O + Cd2+/in | Schizosaccharomyces pombe | ABC transporter, HMT-1, confers tolerance to cadmium. HMT-1 is not essential for vacuolar phytochelatin sequestration. HMT-1 either does not transport Cd-PC complexes or is not the principal Cd-PC/apoPC transporter | ADP + phosphate + Cd2+/in | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | Q9VF20 | - |
- |
| Schizosaccharomyces pombe | - |
wild-type strain YF01 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Cd2+/in | - |
Schizosaccharomyces pombe | ADP + phosphate + Cd2+/out | - |
? | |
| ATP + H2O + Cd2+/in | - |
Drosophila melanogaster | ADP + phosphate + Cd2+/out | - |
? | |
| ATP + H2O + Cd2+/in | ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration | Drosophila melanogaster | ADP + phosphate + Cd2+/out | - |
? | |
| ATP + H2O + Cd2+/in | ABC transporter, HMT-1, confers tolerance to cadmium. HMT-1 is not essential for vacuolar phytochelatin sequestration. HMT-1 either does not transport Cd-PC complexes or is not the principal Cd-PC/apoPC transporter | Schizosaccharomyces pombe | ADP + phosphate + Cd2+/in | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 97900 | Drosophila melanogaster |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| heavy metal tolerance factor 1 | - |
Schizosaccharomyces pombe |
| heavy metal tolerance factor 1 | - |
Drosophila melanogaster |
| HMT-1 | - |
Schizosaccharomyces pombe |
| HMT-1 | - |
Drosophila melanogaster |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Schizosaccharomyces pombe | |
| ATP | - |
Drosophila melanogaster | |
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