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Literature summary for 7.2.2.2 extracted from

  • Falcon-Perez, J.M.; Mazon, M.J.; Molano, J.; Eraso, P.
    Functional domain analysis of the yeast ABC transporter Ycf1p by site-directed mutagenesis (1999), J. Biol. Chem., 274, 23584-23590.
    View publication on PubMed
Search for more literature for 7.2.2.2

Protein Variants

Protein Variants Comment Organism
A910G mutants more sensitive to Cd2+ than wild type strain, higher activity for glutathione S-conjugated leukotriene C4 Saccharomyces cerevisiae
D777N mutants exhibit a Cd2+ hypersensitive phenotype, partially reduced transport activity for glutathione S-conjugated leukotriene C4 Saccharomyces cerevisiae
D821G mutants with Ycf1p in vivo activity as wild type strain Saccharomyces cerevisiae
E709Q mutants with Ycf1p in vivo activity as wild type strain Saccharomyces cerevisiae
E927K mutants exhibit a Cd2+ hypersensitive phenotype Saccharomyces cerevisiae
G1306E mutants exhibit a Cd2+ hypersensitive phenotype, abolished transport activity for glutathione S-conjugated leukotriene C4 Saccharomyces cerevisiae
G1311R mutants exhibit a Cd2+ hypersensitive phenotype, abolished transport activity for glutathione S-conjugated leukotriene C4 Saccharomyces cerevisiae
G1413D mutants exhibit a Cd2+ hypersensitive phenotype Saccharomyces cerevisiae
G663V mutants exhibit a Cd2+ hypersensitive phenotype, abolished transport activity for glutathione S-conjugated leukotriene C4 Saccharomyces cerevisiae
G756D mutants exhibit a Cd2+ hypersensitive phenotype, abolished transport activity for glutathione S-conjugated leukotriene C4 Saccharomyces cerevisiae
G835R mutants more sensitive to Cd2+ than wild type strain, partially reduced transport activity for glutathione S-conjugated leukotriene C4 Saccharomyces cerevisiae
I711S mutants exhibit a Cd2+ hypersensitive phenotype Saccharomyces cerevisiae
I840P mutants more sensitive to Cd2+ than wild type strain, partially reduced transport activity for glutathione S-conjugated leukotriene C4 Saccharomyces cerevisiae
L817S mutants more sensitive to Cd2+ than wild type strain Saccharomyces cerevisiae
L825T mutants more sensitive to Cd2+ than wild type strain Saccharomyces cerevisiae
L826S mutants more sensitive to Cd2+ than wild type strain, partially reduced transport activity for glutathione S-conjugated leukotriene C4 Saccharomyces cerevisiae
additional information deletion of L712 and F713, mutants exhibit a Cd2+ hypersensitive phenotype Saccharomyces cerevisiae
N1366K mutants exhibit a Cd2+ hypersensitive phenotype, partially reduced transport activity for glutathione S-conjugated leukotriene C4 Saccharomyces cerevisiae
Q1148P mutants more sensitive to Cd2+ than wild type strain Saccharomyces cerevisiae
R1143C mutants more sensitive to Cd2+ than wild type strain, partially reduced transport activity for glutathione S-conjugated leukotriene C4 Saccharomyces cerevisiae
Y855L mutants more sensitive to Cd2+ than wild type strain, higher activity for glutathione S-conjugated leukotriene C4 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
tonoplast
-
 Saccharomyces cerevisiae
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Cd/cytoplasm + ATP + H2O Saccharomyces cerevisiae
-
 Cd/vacuole + ADP + phosphate
-
 ?
glutathione S-conjugated leukotriene C4/cytoplasm + ATP + H2O Saccharomyces cerevisiae
-
 glutathione S-conjugated leukotriene C4/vacuole + ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cd/cytoplasm + ATP + H2O
-
 Saccharomyces cerevisiae Cd/vacuole + ADP + phosphate
-
 ?
glutathione S-conjugated leukotriene C4/cytoplasm + ATP + H2O
-
 Saccharomyces cerevisiae glutathione S-conjugated leukotriene C4/vacuole + ADP + phosphate
-
 ?