Literature summary for 7.2.2.14 extracted from

Moomaw, A.S.; Maguire, M.E.
Cation selectivity by the CorA Mg2+ channel requires a fully hydrated cation (2010), Biochemistry, 49, 5998-6008.

Search for more literature for 7.2.2.14

Protein Variants

Protein Variants	Comment	Organism
E281A	the mutant shows no significant changes in apparent Mg2+ affinity	Salmonella enterica
E281K/K287E	the apparent cation affinity of the double mutant is identical to that of wild type enzyme	Salmonella enterica
E281L	the mutant shows no significant changes in apparent Mg2+ affinity	Salmonella enterica
E281Q	the mutant shows no significant changes in apparent Mg2+ affinity	Salmonella enterica
E281R	the mutant shows no significant changes in apparent Mg2+ affinity	Salmonella enterica
E285A	non-functional mutant	Salmonella enterica
E285D	non-functional mutant	Salmonella enterica
E285K	non-functional mutant	Salmonella enterica
E285Q	non-functional mutant	Salmonella enterica
E285R	non-functional mutant	Salmonella enterica
K287E	the mutation demonstrates a modest decrease in apparent Mg2+ affinity of 2-4fold, the mutation does not affect enzyme function significantly, although apparent Mg2+ affinity is decreased about 10fold	Salmonella enterica
K287Q	the mutation does not affect enzyme function significantly, although apparent Mg2+ affinity is decreased about 10fold	Salmonella enterica
K287R	the mutation does not affect enzyme function significantly, although apparent Mg2+ affinity is decreased about 10fold	Salmonella enterica

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	a significant part of the selectivity for Mg2+ derives from binding the fully hydrated cation	Salmonella enterica

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica	P0A2R8	serovar typhimurium	-

Subunits

Subunits	Comment	Organism
homopentamer	-	Salmonella enterica

Synonyms

Synonyms	Comment	Organism
CorA	-	Salmonella enterica

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Release 2023.1 (January 2023)